|One of the lead scientists is so convinced that the 10% life-extension the resear- chers observed in rodents will occur in humans, as well, that he is already taking glucosamine supps everyday!|
Yes! I am even in for skipping carbs altogether, but not for a lifetime (!) which is what would be necessary to reproduce the life-extending effects Schulz et al. observed in their 2007 study on the effects of carbohydrate restriction on the lifespan of the notorious (not B.I.G but) B.I.R. as in "big bad roundworm" (Schulz. 2007).
Now, about seven years later, my favorite anti-ROS-theory-of-aging researcher Michael Ristow and his colleagues some of whom had been involved in the previously cited experiment as well was able to show that bathing the worms in glucosamine will elicit similar life-extending effects (Weimer. 2014).
With only 5% the overall increase in life-expectancy was yet significantly lower than in the "carb restriction" study from 2007, but - and that's actually way more important - unlike cutting carbs, which had failed to produce any effects in a rodent model, the mice who received the glucosamine as an adjunct to their diet, when they were already 100 weeks of age (in human years that's approximately 65 years) lived almost 10% longer than their peers in a non-glycosamine-enhanced control group.
Just to make that clear: We are talking about around 8 additional years of human lifespan! If the results translate from a small mouse who does not stuff itself with junk food all day to the average fast-food addicted Westerner, who follows Winston Churchill's motto "No sports!"Even if the life-extension did not work, though, couch potato and aging athlete will would probably both benefit from the pronounced improvements / amelioration of the age-induced defects in glucose control, which were significantly reduced in the rodents on the high glucosamine groups.
|Figure 1: The decreased ATP stores that come with the "low carb mimicry" effect are not exactly what someone who wants to hit the weights in his old age, would want (Weimer. 2014)|
In view of the fact the both groups of mice consumed identical amounts of carbohydrates, it's thus only logical to assume that the provision of adequate amounts of glucosamine inhibits the use of glucose from the diet and will thus yield similar metbolic (side) effects as a real low-carb diet - yet without having to skip on pasta, pizza and (of course ;-) tons of sweet potatoes.
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- Weimer, Sandra et al. "D-Glucosamine supplementation extends lifespan of nematodes and of ageing mice." Nature Communications (2014), doi: 10.1038/ncomms4563