The Gluten Solution: Aspergillus Niger-Derived Enzyme May Make "Gluten-Free" Redundant - Enzyme Supplementation Reduces the Amount of Gliadin in the Duodenum by 80-90%
Can a pill simulate "gluten-free"? |
More recently, though, studies have shown that less pronounced adverse reactions to gluten consumption can occur even in subjects who don't suffer from coeliac disease. As Salden et al. point out, "[p]resently non-coeliac gluten sensitivity has been clinically recognised as a separate condition in which neither allergic nor autoimmune mechanisms are involved" (Salden. 2015). Accordingly, the results of the latest study from the Maastricht University Medical Center are relevant for much more than just 1% of the population (West. 2003; Mäki. 2003; Fasano. 2003; Bingley. 2004).
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Table 1: Recipe and nutritional composition of the low and high calorie test meal per 300 g portion (Salden. 2015). |
The gastric emptying was tracked with acetaminophen and a triple-lumen catheter was used to get the gastric and duodenal samples that were used to calculate the 240-min area under the curve (AUC0–240 min) of α-gliadin concentrations.
Is Noneliac Gluten Sensitivity Legit? A Review of the Latest Scientific Evidence on NCGS by Alex Leaf (Guestpost) | more |
Ok, it's questionable whether it's feasible to put a gliadin digesting enzyme into goods without impairing their quality (gluten is after all added for its ability to "glue" things together; putting AN-PEP into the dough may thus ruin it).
A pill with Aspergillus niger prolyl endoprotease (AN-PEP), on the other hand, could make the life of people who risk developing diarrhea or other symptoms of gluten intolerance whenever they eat out significantly easier... ah, and it could be big business in view of the contemporary gluten-scare, which brings me to the sponsors of the study (DSM Nutritional Products AG) who are about to use the study to advertise their AN-PEP products which have already been approved by the French Agency for Food, Environmental and Occupational Health & Safety | Comment on Facebook!
- Bingley, Polly J., et al. "Undiagnosed coeliac disease at age seven: population based prospective birth cohort study." Bmj 328.7435 (2004): 322-323.
- Fasano, Alessio, et al. "Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study." Archives of internal medicine 163.3 (2003): 286-292.
- Mäki, Markku, et al. "Prevalence of celiac disease among children in Finland." New England Journal of Medicine 348.25 (2003): 2517-2524.
- Piper, Justin L., Gary M. Gray, and Chaitan Khosla. "Effect of prolyl endopeptidase on digestive-resistant gliadin peptides in vivo." Journal of Pharmacology and Experimental Therapeutics 311.1 (2004): 213-219.
- Salden et al. "Randomised clinical study: Aspergillus niger-derived enzyme digests gluten in the stomach of healthy volunteers." Alimentary Pharmacology and Therapeutics (2015): Accepted manuscript.
- West, J., et al. "Seroprevalence, correlates, and characteristics of undetected coeliac disease in England." Gut 52.7 (2003): 960-965.