|No, I still do not recommend the chronic (ab-)use of NSAIDs, bro.|
As you may remember, previous studies have yielded conflicting evidence with respect to the ability of NSAID to accelerate muscle healing and thus accelerater and ultimately shorten the adaptational process.
In the study at hand, the authors did therefored recruit 32 untrained, but healthy young men and randomly assigned them to consume either NSAID [1200 mg/d ibuprofen (IBU)] or placebo (PLA) daily for 2 wk before and 4 wk after an electrical stimulation–induced injury to the leg extensor muscles of one leg.
To assess, whether the ingestion of ibuprofen would, as the scentists suspected alter satellite cell response and time course of regeneration in the experimentally injured skeletal muscle of young healthy men, biopsies were collected from the vastus lateralis muscles before and after stimulation (2.5 h and 2, 7, and 30 d) and were assessed for satellite cells and regeneration by immunohistochemistry and real-time RT-PCR. In conjunction with the likewise measured length of the telomeres, the scientists expected to be able to determine the actual effect of NSAIDs on the post-exercise recovery process.
The bad news is that the chronic consumption of NSAIDs is nothing a healthy individual should consider - even if it prevents your muscle from collagen depositions (see Figure 1, right); and still, if we could get the benefits observed in the study at hand without the potential long-term side effects of common NSAIDs, they could be a game changer... at least for elderly individuals, in whom the recruitment of satellite cells and thus process of muscle repair appears to be impaired by aging.
- Mackey, Abigail L., et al. "Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti-inflammatory medication." The FASEB Journal (2016): fj-201500198R.