IGF1/GH Blance: Determining Factor of Longevity!?

Next to plain testosterone GH and IGF-1 doping has attracted more and more attentions from bodybuilders and athletes all over the world. Being propagated as recompositioning agents, the injection of growth hormone (GH) or peptides triggering the release thereof is already common practice among juicers, who might have a genuine interest in the results of a recent study by Marino et al. (Marino. 2010). The scientists investigated the effect of insulin-like growth factor (IGF-1) in a mouse-model of human premature aging, whose main characteristic is a high GH/IGF1-quotient - something you would also expect in bodybuilders injecting exegenous growth hormone. The scientists found:

IGF-1 treatment restores the proper balance between IGF-1 and GH in Zmpste24^-/− mice, delays the onset of many progeroid features, and significantly extends the lifespan of these progeroid animals.

Although the scientists investigated a pathological model, chances are that doping induced changes in the IGF1/GH ratio could shorten the lifespan of juicers appear very real.