Study Underlines Real World Benefits of 2g/day of Ginger for Type II Diabetics - Effects Almost on Par W/ Metformin
|If you don't have ginger powder, just shred a fresh rhizome. That's by the way what the researchers did, as well.|
But do we know, whether the regular consumption of realistic amounts of pure ginger will have beneficial effects on the glucose levels of those who would benefit the most, i.e. type II aka "lifestyle" diabetics?
The results of the latest study from the Tehran University of Medical Sciences where scientists obviously don't depend on being able to produce patentable agents would suggest: There are benefits!
I have to admit, though, the ginger the 20-60 years old diabetics consumed was not provided in form of whole roots, but rather as a powder made of ginger roots.
"The under study patients were diagnosed with non-insulin dependent diabetes mellitus (NIDDM) by an endocrinologist on the basis of the results of the blood tests and met the criteria of the study. These criteria included: disease duration at least 2 years, HbA1c level of 6-8%, taking no antioxidant supplements such as selenium, zinc and beta-carotene for at least 3 months prior to the study, no smoking and drinking. Exclusion criteria of the study were insulin therapy at baseline or during the study, changes in the type or dose of medication, changes in diet or daily physical activity, any acute illnesses or some chronic diseases including kidney, liver, cardiovascular, and gastrointestinal diseases, smoking pregnancy and lactation, consumption of ginger or other botanical supplements, ginger hypersensitivity, and consumption of less than 80% of supplements during the study period." (Khandouzi. 2015)Patients were divided randomly into two groups (experiment and control, 25 subjects in each) using computer's random numbers to receive either ginger or placebo one capsule twice a day for 12 weeks. All subjects were permitted to consume their usual medications according to their physician's recommendation.
Regular ginger powder, nothing else!
The fresh rhizomes for the ginger powder purchased from local market and were ground as a fine particle after drying. The powder was delivered to a pharmaceutical lab (Tehran university of medical sciences, Iran) to prepare capsules containing 1 gram ginger in each. Lactose was also used to make placebo. Information on when the supplements were ingested is unfortunately, not available, but I assume "twice daily" means with breakfast and dinner or something like that.
|Figure 1: Changes in fasting blood sugar, HbA1C, Apo-B/Apo-A1 and MDA levels (Khandouzi. 2015).|
- A 12% and 10% reduction in fasting blood glucose and HbA1c that may reduce many of the nasty chronic side effects of type II diabetes, such as its negative effects on heart health (Patel. 2008)
- A 28% reduction in the Apo B / Apo A-I ratio that signifies a significant reduction in coronary atherosclerosis risk (Van Stiphout. 1986)
- A 23% reduction in malondialdehyde (MDA) levels that signifies a reduction in coronary heart disease risk (Khan. 2000)
- Khan, Mudassir Ahmad, and Abdul Baseer. "Increased malondialdehyde levels in coronary heart disease." J Pak Med Assoc 50.8 (2000): 261-264.
- Khandouzi, Nafiseh, et al. "The Effects of Ginger on Fasting Blood Sugar, Hemoglobin A1c, Apolipoprotein B, Apolipoprotein AI and Malondialdehyde in Type 2 Diabetic Patients." Iranian Journal of Pharmaceutical Research: IJPR 14.1 (2015): 131.
- Patel, Anushka, et al. "Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes." (2008).
- Schweizer, A., et al. "Comparison between vildagliptin and metformin to sustain reductions in HbA1c over 1 year in drug‐naïve patients with Type 2 diabetes." Diabetic Medicine 24.9 (2007): 955-961.
- Van Stiphout, W. A. H. J., et al. "Is the ratio of apo B/apo AI an early predictor of coronary atherosclerosis?." Atherosclerosis 62.2 (1986): 179-182.