|Figure 1: Effects of Coumarins from F. rhynchophylla on Adipocyte Differentiation|
in 3T3-L1 Cells on days 1-6 (Shin. 2010)
Esculetin (1) significantly blocked induction of PPARg expression in differentiated adipocytes, as measured by Western blot analysis (Fig. 4). In addition, esculetin (1) significantly inhibited adipocyte differentiation induced by troglitazone, a PPARg agonist (Fig. 5). These results suggest that esculetin (1) inhibited adipogenic differentiation, in part, via inhibition of PPARg -dependent pathway.If the results can be reproduced in vivo, supplementing with Fraxinus rhynchophylla bark may prove a preventive measure against adiposity. If, however, you are already fat and dieting, inhibition of adipocyte differentiation won't be your major concern, anyway.