Sunday, January 2, 2011

Oral ATP Supplementation Proves Completely Ineffective Even at Very High Doses

I think most supplement companies have hitherto given up on convincing you of the use of oral ATP supplements. About 2 month ago, I did however notice a new "high dosed" product (I cannot remember the figures out of my head, but the daily dose was far below 1.000mg) was released to be bought by the in-educated public ;-)

Just to discourage you from wasting your money on any such products, here is a very recent study (Coolen. 2010) on the futility of attempting to rise ATP levels via oral supplementation:
Thirty-two healthy subjects were randomised to receive 0, 250, 1250 or 5000 mg ATP per d for 28 d by means of enteric-coated pellets. In addition, on days 0 and 28, all thirty-two subjects received 5000 mg ATP to determine whether prolonged administration would induce adaptations in the bioavailability of ATP. ATP supplementation for 4 weeks did not lead to changes in blood or plasma ATP concentrations. Of all ATP metabolites, only plasma uric acid levels increased significantly after the administration of 5000 mg of ATP.
If you are an athlete and really intend to raise ATP levels orally, creatine supplementation (and thus increased ATP resynthesis) would be one way to go.