|Image 1: This would be a case where metformin probably won't help you to get your menses back - unless this is just one of your "yous" and you are taking high doses of anti-psychotics, of course.|
- Differential effects of green and black tea on prostate cancer risk
While we are, yet again, only dealing with epidemiological shenanigan
in a population living in a, if not the juggernaut of the far east, the
>50% increase in hazard risk in the 27,293 men from the Singapore
Chinese Health Study Julia A. Montague and her colleagues report for men
who drink 1 cup of black tea per day is somewhat alarming (Montague.
2012). The fact that the hazard risk decreases to +17% with more than 2
cups of black tea does yet suggest that this is nothing but a statistic
outlier. That said, black tea is (at least based on the results of this
study) overall probably as benign as green tea, which is totally devoid
of statistical beneficial or detrimental effects on prostate cancer risk
in this cohort of normal-weight men in their middle to late 50s.This result does by the way not conflict with previous research, which did - if anything - only suggest a "borderline significant" beneficial effect of green tea and absolutely no effect of black tea on prostate cancer risk (Zheng. 2012). Apropos prostate cancer, just in case you missed it I highly suggest you take a look at my brief write-up on the recently published "red meat will give you prostate cancer study" before you decide on whether or not you got to stop eating meat for the sake of your prostate.
Figure 1: If ~50g of leucine and alanine /kg chow are good, then 500g of whey are magic; makes you wonder, why you would want to add just one amino acid, instead of more protein, no?While the high fat + complete protein mice hardly gained any body fat, the high fat + leucine and high fat + alanine (both diets were "adequate" in protein and contained 100g whey + 60g leucine and 100g whey + 45g alanine, respectively) got only significantly less fat compared to their peirs on the 100g whey only diet control HFD diet. Now, the high protein mice (500g of whey per kg chow; =5x over baseline) simply consumed less energy, but so did the mice on the leucine and alanine enhanced diets, so that the title of the study is not just misleading, it also disguises the most important result of the study, which is high protein diets keep mice lean.
- "Cure-it-all-drug" metformin helps with anti-psychotic induced amenorrhea and weight gain, as well. If
metformin was not (a) no longer protected by patent rights and (b)
would not basically work via similar mechanisms as exercise I would
really begin to smell fraud over the ever-extending list of pathologies
this 1920s medication is good for (this is when it was originally
discovered, it took however until 1958 before researchers realized the
potentials and a pharma company introduced it to the UK market). New to
the list are the negative side-effects women experience in response to
anti-psychotic treatments. In a recently documented experiment, 48 women
(ages 18-40 years) with amenorrhea and weight gain in response to
clozapine, olanzapine, risperidone, or sulpiride (all anti-psychotic
drugs administered to treat schizophrenia) received a dose of 1,000mg of the wonder-molecule per day (Wu.
2012). After 2 months 25% of the women had resumed menstruation, after another 2
weeks it were 80% and after 3 months all women were eumenorrheic,
again (of the placebo group only 2 resumed menstruating). Instead of
gaining another 2kg of body weight, they had lost 2kg and the previously
thwarted prolactin, LH, and testosterone levels, as well as the LH/FSH
ratio had normalized. Probably, some of you may now ask themselves: Will this work for me as well - though I am not taking anti-psychotics? I would love I could answer this question, but aside from polycystic ovarian syndrome (PCOS), where we have a couple of trials in which metformin was used with success (cf. Velazquez. 1998; Bela. 2009; Palomba. 2009), the scientific evidence is scarce and in view of the fact that we know even less about the underlying mechanisms by which risperidone & co cause amenorrhea and weight gain than about the almost magical omnipotence of metformin I honestly can't tell. One thing that comes mind, where metformin is yet very unlikely to of any use is diet or exercise induced amenorrhea (overtraining and undereating), because this form of amenorrhea presents with a totally different hormonal profile, with low levels of basically all reproductive hormones.
- Stevia as cortisol promoter? Case study: Bloating, high blood pressure and malaise in a young previously healthy woman. Before I go on, let me briefly remind you that the events that are described in a recent case report from the University of Iowa Hospitals and Clinics
may should be regarded with the degree of caution that is indicated
whenever we are talking about case reports, specifically because stevia
does actually have a pretty decent safety profile (aside from the
occasional allergic reactions you will see with almost every foreign
molecule you put into your body, obviously). Now, I am certainly not suggesting that this is going to happen to everyone, but it could well be that the frequent reports of headaches people are developing after a couple of days "on stevia", could also be related to the effects the sweetener has on people with a certain genetic disposition. So, if you get a headache or start holding water like crazy, when you use stevia / stevia sweetened products, first try using a different brand (there have been issues with toxins in some products), make sure you have a pure stevia sweetener and not one with other sweeteners added (thx. to Amit for the reminder about erythritol that's in many products), switch to another preparation, e.g. from pure stevisoids to a a more "natural" extract and if all that does not help, just turn your back on it - you can live without it, I guarantee ;-)
- Omega-3's modulate adrenal activity What many people know from going overboard on fish oil has now been established in a recently published rodent study by Marie
Hennebelle and her French (resident) colleagues (Hennebelle. 2012). The
researchers fed a group of rodents a totally ALA free energetically
restricted diet to produce male rats with brain phospholipid DHA levels
that were 50% lower than those of the normal control. The 6 month-old
rodents were then subjected to chronic restraint stress (6 h/d) for
21 days. As expected the rodents on the alpha linolic acid deficient
diets had a much harder time coping with the torture they were exposed
to and showed higher corticosterone levels, more pronounced behavioral
abnomalies and slightly more pronounced weight loss in the 3-4 week of
the 1-month experimental period. What's intriguing though is the the
remarkable stress resistance (one could also say adrenal hypofunction
;-) in the rodents in a third experimental group, who had received an
omega-3 enriched diet that boosted their brain DHA levels to 10% above
normal: Compared to both the normal, as well as the omega-3 deprived
rodents they had ~30% lower cortisol levels during week two and three of
the experiment and lost only 50% of the weight their normal and ALA
deprived peers did. That this is not necessarily a good thing for everyone is probably nothing I have to tell you. After all, the number of people who are hardly functioning due to over-supplementation with fish oil and (as this study would suggest) below normal stress responses is ever increasing. As with so many nutrients and supplements, it thus comes down to specificity and hitting the right ratios for you as an individual, again. And what's most important: Before you even start thinking about "fixing your adrenals" you should first take a look at the various stressors in your life. After all, the aforementioned fatigue is not simply a result of two much fish oil, but of its combination with a lifestyle which simply requires a robust and healthy cortisol response. You would not smoke weed to calm yourself down minutes before running away from a saber-toothed tiger, either, would you?
Video 1: These young ladies show you how it's done - well almost, you better go a little slower (click image to watch.What is yet important is that you stick to an adequate temp and don't mess around and hurt yourself. In the study at hand, the velocity of the movement was standardized to 30°/s. If we assume that you go over the full ROM it must therefore take you 3s until your nose hits the ground (if you are afraid to hurt your nose, you may be interested in the SuppVersity EMG Series and the Best Leg + Hamstring Exercises ;-)
- Billa E, Kapolla N, Nicopoulou SC, Koukkou E, Venaki E, Milingos S, Antsaklis A, Adamopoulos DA. Metformin administration was associated with a modification of LH, prolactin, and insulin secretion dynamics in women with polycystic ovarian syndrome. Gynecol Endocrinol 2009; 25:427–434
- Esmail S, Kabadi UM. Edema, Enigma: 11 B-Hydroxysteroid dehydrogenase Type 2 Inhibition by Sweetener “Stevia”. Open Journal of Endocrine and Metabolic Diseases, 2012, 2, 49-52.
- Freudenberg A, Petzke KJ, Klaus S. Dietary L-leucine and L-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity. Amino Acids. 2012 Jul 31.
- Hennebelle M, Balasse L, Latour A, Champeil-Potokar G, Denis S, Lavialle M, Gisquet-Verrier P, Denis I, Vancassel S. Influence of omega-3 Fatty Acid status on the way rats adapt to chronic restraint stress. PLoS One. 2012;7(7):e42142.
- Montague JA, Butler LM, Wu AH, Genkinger JM, Koh WP, Wong AS, Wang R, Yuan JM, Yu MC. Green and black tea intake in relation to prostate cancer risk among Singapore Chinese. Cancer Causes Control. 2012 Aug 3.
- Palomba S, Falbo A, Zullo F, Orio F Jr. Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. Endocr Rev 2009; 30:1–50
- Wu RR, Jin H, Gao K, Twamley EW, Ou JJ, Shao P, Wang J, Guo XF, Davis JM, Chan PK, Zhao JP. Metformin for treatment of antipsychotic-induced amenorrhea and weight gain in women with first-episode schizophrenia: a double-blind, randomized, placebo-controlled study. Am J Psychiatry. 2012 Aug 1;169(8):813-21.
- Velazquez EM, Mendoza S, Hamer T, Sosa F, Glueck CJ. Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure while facilitating normal menses and pregnancy. Metabolism 1994; 43:647–654
- Zheng J, Yang B, Huang T, Yu Y, Yang J, Li D. Green tea and black tea consumption and prostate cancer risk: an exploratory meta-analysis of observational studies. Nutr Cancer. 2011;63(5):663-72.