|Is it true that you can lose fat without dieting or additional exercise if you supplement with raspberry ketones?|
The corresponding study involved 12 healthy athletic men aged 20 to 22 years old. Young men whose activity levels ranged from moderately active (participated in physical activity equivalent to walking 1.5 to 3 miles per day along with typical day-to-day physical activity) to vigorously active (participated in jogging, running, circuit training, competitive sports and heavy labor or housework).
The participants were asked to sign a waiver agreeing to standardize their lives as much as possible including maintaining a uniform, diet and workout routine and restrict other weight loss supplement use during the 3 week testing period to exclude that sudden lifestyle or diet changes would thwart the results of the randomized controlled trial, in the course of which the subjects were randomly assiged to one of the following three groups:
- placebo - the placebo group was given capsules containing powdered sugar
- low treatment group - the low treatment group took 125 mg capsules w/ raspberry ketones
- high treatment group - the high treatment group took 250 mg capsules w/ raspberry ketones
|Effect of raspberry ketone liver and visceral adipose tissue weight (B) in mice fed a high-fat diet for 10 wks (Morimoto. 2005).|
Addendum: Good question from my friend Carl Lanore who asked about the name "raspberry ketones" and whether that means that "regular ketones" would have similar effects. Without going too much into chemical details, it can be said that the structure of "raspberry ketones" has nothing to do with the ketone bodies you probably think about (beta-hydroxybutyrate). In fact, their molecular structure is more like the one of capsaicin and synephrine (Morimoto. 2005) - a structural similarity that may also explain their effects on the mammalian fatty acid metabolism.
|Figure 1: Change in Body Composition per Treatment Group (Pagani. 2015).|
body fat percentage in the high treatment group (p = 0.007) as presented in Figure 1. Additionally, no significant difference was found in the low treatment group (p= 0.359), nor the control, or placebo, group (p = 0.405).
- Morimoto, Chie, et al. "Anti-obese action of raspberry ketone." Life sciences 77.2 (2005): 194-204.
- Pagani, Angelo, and John Thistlethwaite. The Effects of Raspberry Ketone Supplementation on Body Composition. Diss. Ohio Dominican University, 2015.
- Park, Kyoung Sik. "Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes." Planta medica 76.15 (2010): 1654.
- Wang, Lili, Xianjun Meng, and Fengqing Zhang. "Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis." Journal of medicinal food 15.5 (2012): 495-503.