Possible Side Effects of 17β-estradiol and Tamoxifen Treatment
Treatment with estrogens, mainly in women, and selective estrogen modulators (SERMS), which are also interesting for the average juicer, may yield hitherto unknown metabolic side effects. Scientists from Portugal ( Moreira. 2010 ) have found that both, tamoxifen as well as estrogen treatment influence the oxidative capacity of mitochondria: Fig. 1. Effects of E2 and/or TAM treatments on glutathione levels of liver, heart and brain mitochondria. ( Moreira. 2010 ) In spite of the distinct effect on glutathione levels, their effect on lipid peroxidation appears to be contrary: TBARS levels were used to determine the extension of lipid peroxidation (PX) induced by the pro-oxidant pair ADP/Fe 2+ . Fig. 3 A shows that liver mitochondria isolated from E2 + TAM females in the presence of ADP/Fe 2+ produced significantly lower levels of TBARS when compared with liver mitochondria isolated from the other groups of experimental animals. No significant alterations were ob...