|Figure 1: Effect of HFD and taurine supplementation on weight gain at days 0 and 35 of feeding. |
Each value is expressed in grams. (Mesallamy. 2010. Fig. 1)
Fructose-fed rats showed significantly impaired glucose tolerance, impaired insulin sensitivity,While the human equivalent dose of the 300mg/kg taurine used in the study is about 100mg for a person weighing 70kg, previous studies on the positive health effects of taurine have used 1.5-3.0g of taurine - and this would also be my suggestion for those of you who have now become interested in the health benefits of this sulfur-amino acid.
hypertriglyceridemia, hypercholesterolemia, hyperhomocysteinemia (HHcy), lower total antioxidant capacity (TAC), lower paraoxonase (PON) activity, and higher nitric oxide metabolites (NOx) concentration, when compared to rats fed on control diet. Supplementing the fructose-fed rats with taurine has ameliorated the rise in HOMA by 56%, triglycerides (TGs) by 22.5%, total cholesterol (T-Chol) by 11%, and low density lipoprotein cholesterol (LDL-C) by 21.4%. Taurine also abolished any significant difference of TAC, PON activity and NOx concentration among treated and control groups. TAC positively correlated with PON in both rats fed on the HFD and those received taurine in addition to the HFD.