|Image 1: T2-based fat burners work!|
At least when interperitoneally
injected in overfed rats ;-)
To assess the effects of 3,5 diiodo-L-thyronine on non-hypothyroid, yet overfed animals, Maria Moreno and her colleagues fed three groups à 15 male Wistar rats (aged 8 weeks, body weight 300+/-5g) either a normal (measured by rat standards ;-) low fat or the infamous high-fat diet, scientists use to induce a pathology that is generally accepted as a model for human obesity and the metabolic syndrome.
|Figure 1: Energy content and composition of control and high fat diet in kcal/g of body weight|
(data adapted from Moreno. 2011)
The HFD-induced increases in muscle levels of fatty acid translocase (3-fold; P<0.05) and TGs (2-fold, P<0.05) were prevented by T2 (each; P<0.05 vs. HFD). T2 increased insulin-stimulated Akt phosphorylation levels (~2.5-fold; P<0.05 vs.HFD). T2 induced these effects while sparing muscle mass and without cardiac hypertrophy [both side-effects commonly observed if the same effects are triggered by administration of T3]. T2 increased the muscle contents of fast/glycolytic ﬁbers (2-fold; P<0.05 vs. HFD) and sarcolemmal glucose transporter 4 (3-fold; P<0.05 vs. HFD).Unfortunately, from a dieters perspective, who will obviously be in a caloric deficit and does not want to ward fat gains off, but to get rid of his/her love-handles, these results are hardly significant. As it was the case in the previous studies by the same group, the model, the scientists used (hyperthyroid animals in previous studies; overfed animals in the study at hand) does not allow for a definitive conclusion on whether or not 3,5 diiodo-L-thyronine, let alone its short acting (cf. Lanni. 1994) "brother" 3,5,3' diiodo-L-thyronine, would facilitate fat loss in healthy (i.e. non-hypothyroid) human beings on a calorically restricted weight loss diet. That being said, the present data allows for the hypothesis that it could ameliorate the detrimental effects of caloric restriction on thyroidal determined parameters of basal metabolism and, at the same time, prevent muscle breakdown via the insulin-dependent upregulation of muscle protein synthesis by increased Akt phosphorylation.
|Figure 2: Cholesterol, triglycerides and body weight after 8 weeks of high fat feeding in rats with and without T2 injections relative to values of normal-fed controls (data calculated based on Moreno. 2011)|
- keep you lean due to its beneficial effects on energy expenditure in a state of nutrient overabundance
- help you build & restructure lean muscle via its effects on protein synthesis and muscle fiber type composition [note: a switch towards fast-twitch type-II muscle fibers will not only make you stronger, it will also help you