Yohimbine as an Ergogenic? 5mg of Yohimbine 2h Before Cycling to Exhaustion Increase Time to Exhaustion by 29%, Energy Expenditure & Fatty Acid Oxidation by >10%

Many people take yohimbine before cycling, but few know that it's not just increasing fat loss, but also their cycling performance on the bike.
Yes, it's not exactly what most people use yohimbine for. Rather than for ergogenic purposes, yohimbine is usually use do lose fat and, more specifically, to target "stubborn body fat" (find out if that works).

A recent study from the Al-Mustansiriya and Kabala Universities did yet find that "yohimbine accelerates and improves cycling performances via positive ergogenic effects" (Al-Kuraishy. 2014). If this is actually true, the authors, Al-Kuraishy and Abood, would in fact be right to say that "yohimbine can be used as ergogenic agent for ameliorating the physical fatigue" (Al-Kuraishy. 2014).
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But let's do one step after the other and take a brief look at what exactly the Iraqis did. The subjects of the study were medical students. 20 male volunteers who joined a single blind random experimental study. The exercise program consists of cycling on an ergometer. Pulse was measured using ear pulse sensor and maximum pulse rate achieved in this study and the entire exercise parameters were recorded as baseline data.

In the subsequent non-blinded test with yohimibine, the subjects took a sinlge 5 mg yohimbine tablet (orally) 2h before they jumped onto the bike again, where they performed another standardized cycling ergometer test to fatigue state.
Figure 1: 5mg of yohimbine ingested 2h before the standardized cycling test to exhaustion lead to significantly improved cycling power, energy expenditure, distance and time to exhaustion as well as cycling speed; values expressed relative to category mean, percentages above the bar indicate the relative performance increment w/ yohimine (Al-Kuraishy. 2014).
The results show that yohimbine significantly improved all ergogenic parameters (efforts, calories, distance, speed and exercise time) from baseline after single oral dose of 5mg (Figure 1) - all with p-values were p < 0.05 which indicates statistical significance for the observed difference with vs. without yohimbine.

Moreover, the authors found that yohimbine significantly accelerated the oxygen consumption at the "fat burning" and maximal intensities and the maximal and resting heart rate of the subjects (p < 0.05 | Figure 2).
Figure 2: Increase in heart rate and maximal oxygen consumption (indicative of increased fatty acid oxidation) with yohimbine relative to control (Al-Kuraishy. 2014).
Bottom line: While there is no doubt that the provision of 5mg of yohimbine (HCL) 2h before the workout lead to significant performance increases in the study at hand. It is questionable, how much of this increase was triggered by a placebo effect.

Since it is however unlikely that you would see a 29% increase in time to exhaustion and significant increases in fat oxidation as they are indicated by the increase in VO2 consumption (Figure 2) being triggered by placebo, we can probably assume that yohimbine is not only a fat burner, but also an endurance supplement that works - most probably - by increasing the consumption of fatty acids and decreasing the reliance on glycogen + little researched effects on the brain (Hagan. 1986; Yan. 1993) | Comment on Facebook!
  • Al-Kuraishy, Hayder M., Haidar AN Abood, and Ali Ismail A. Al-Gareeb. "Ergogenic Effects of Yohimbine: Standardized Cycling Clinical Study." Karbala J. Med. Vol.7, No.2, Dec, 2014
  • Hagan, R. M., and I. E. Hughes. "Yohimbine affects the evoked overflow of neurotransmitters from rat brain slices by more than one mechanism." Journal of Pharmacy and Pharmacology 38.3 (1986): 195-200.
  • Yan, Qing-Shan, Philip C. Jobe, and John W. Dailey. "Noradrenergic mechanisms for the anticonvulsant effects of desipramine and yohimbine in genetically epilepsy-prone rats: studies with microdialysis." Brain research 610.1 (1993): 24-31.
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