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Science Round-Up Seconds: Prostate Cancer Special - Are You Going to Die From or With Prostate Cancer? Plus: What Can be Done to Influence This Fate?

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Today's SuppVersity article revolves around the question what YOU can do to make sure that the procedure this guy is about to endure is the only thing to be afraid of, when you are going to your check ups ;-) Let me just get this out there, if you missed an appointment because you were listening to the show live, yesterday, I am sorry. Carl and I actually went "longer than long". What was originally intended to be a one hour show did end being a 125min podcast. That being said, there is little left for the "Seconds" - at least news-wise. So, I decided to kick off today's installment of the traditional SuppVersity Science Round Up Seconds with a quick hit summary of the bottom line of the show. As far as the details are concerned, I would strongly encourage you to download and listen to the podcast . I am not the one to call his own stuff "highly educational", but I guess even those of you who are already well-versed in this issue will f...

Viscous Circle: Low Testosterone > Increased Visceral Fat > Insulin Resistance > Even Lower Testosterone

E.J. Hamilton and colleges (Hamilton. 2010) investigated the effect of androgen deprivation therapy (ADT) in prostate cancer patients on subcutaneous and visceral fat. There results are far from being surprising: Twelve months ADT increased visceral abdominal fat area by 22% (from 160.8 ± 61.7 to 195.9 ± 69.7 cm 2 ; p<0.01) and subcutaneous abdominal fat area by 13% (from 240.7 ± 107.5 to 271.3 ± 92.8 cm 2 ; p<0.01). Fat mass increased by 14% (+3.4 kg; p<0.001) and l ean tissue mass decreased by 3.6% (-1.9 kg; p<0.001). Insulin resistance (HOMA-IR) increased by 12% (2.50 ± 1.12 to 2.79 ± 1.31, p<0.05). All that by itself is bad enough, but in the end, by the medical suppression of androgens doctors put their poor patients in a viscous circle, from which it will be very difficult to escape, as obesity and insulin resistance will further reduce testosterone production and overall metabolic health regardless of whether they are secondary to low testosterone, come fr...
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