Resveratrol Attenuates Insulin Resistance - Now, We Know Why: Grape Skin Polyphenol Ameliorates Intramuscular Fat Deposition and Improves Mitochondrial β-oxidation in Rats on a High Fat Diet.
Image 1: Grapes - sugary super food and source of resveratrol. Despite the literal "flood" of studies on the myriad of effects high doses of the grape polyphenol, resveratrol, have on isolated cell cultures; little is known about the mechanism behind its ameliorative effect on various symptoms of the metabolic syndrome. Now, a recent study ( Chen. 2011 ) from the Department of Endocrinology at the Huazhong University of Science and Technology in Wuhan, China, sheds some light onto these underlying biological processes. In the paper, which was published in the prestigious medical Journal Metabolism , the authors report the effects of intragastric administration of 100mg/kg resveratrol [human equivalent ~16mg/kg, i.e. ~1.3g for an 80kg adult] to 8-week old SD rats being fat a high fat diet (59% fat, 20% carbohydrate, 21% protein) over a time course of 8 weeks. Compared to the control group that was fed a "low fat...