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Is Low Blood Sugar Obesogenic? Hypoglycemic Episodes Characteristic of Weight Loss Plateaus & Weight Regain - What to Do? Diet, Sleep, Exercise & Mental Work Matter

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Tip: Restore your muscle and liver glycogen after workouts and before long fasts to ensure a smooth transition from glucose to fat utilization. In view of the diabetes pandemic it sounds stupid, when J-P Chaput and A Tremblay write that low blood sugar levels could contribute to the ever-increasing obesity rates in the US and other Western countries. Their reasoning, however, is sound: An increase in blood glucose concentrations results in increased feelings of satiety whereas a drop in blood glucose concentrations has the opposite effect. Chronically low levels of glucose, as well as the glucose excursions we see in the few (still) healthy people after shoveling down packages of twinkies and dingdongs, would thus precipitate overeating and eventually obesity and diabetes. Use alternatives to sugar sweetened beverages if you want to stabilize your blood glucose! Unsatiating Truth About Sweeteners? Will Artificial Sweeteners Spike Insulin? Sweeteners & the Gu...

Mitochondrial Density in Muscle is Key Determinant of Metabolic Flexibility

If you happened to have listened to Carl Lenore's interview with Mike T Nelson's on SuperHumanRadio , last week, you will be familiar with the concept of metabolic flexibility and how important it is for your body to be able to adapt quickly to varying energy demands and sources. A recent study by scientists from the Pittsburgh School of Medicine ( Chomentowski. 2010 ) had a similar background. Along with several markers of metabolic flexibility the group measured intermyofibrillar and subsarcolemmal (SS) mitochondrial content in a sample of forty sedentary adults with a wide spectrum of insulin sensitivity (insulin-sensitive lean subjects, insulin-resistant nondiabetic subjects, and subjects with type 2 diabetes mellitus). Intermyofibrillar mitochondrial content was lower in the insulin-resistant nondiabetic subjects and type 2 diabetes mellitus groups, significantly correlating with glucose disposal in both men (R = 0.72, P < 0.01) and women (R = 0.53, P < 0.01). In co...
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