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Circadian Clock Normalization as Novel Mechanism Behind the Health Benefits of ALA in NAFLD & Diabesity | Plus: ALA For Athletes & the Obese - Yes/No + When to Take It?

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Yes, you can buy alpha lipoic acid as bulk powder, but if you still have intact mucosa and want to keep it intact, I suggest you swallow pills. Alpha lipoic acid aka "ALA" is a natural AMPK agonist that works similar to metformin. Developed by BASF and others as an anti-diabetes medication in the late 20th century, it's now a popular supplement that is prescribed as a "drug" to type II diabetics only rarely and only in Europe, yet not in the US. Based on the currently available evidence its anti-diabetic effects are comparable but far inferior to metformin. In view of the fact that lipoic acid is also non-patentable and thus not exactly profitable, it's no wonder that it has disappeared from the radar of the medical establishment over the past decade. Learn more about lipoic acid here at the SuppVersity ALA Boosts Creatine Uptake ALA + More vs. Migraine What's the Best N3:N6 Ratio? High EAA protein for fat loss ALA = Nutrient-Re...
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True or False: You Can (Ab-)Use Nicotine Chewing Gums to Get Shredded Without Compromising Your Health

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Nicotine gums are made for smokers. Smokers are leaner than non-smokers. Chewing nicotine gums helps you lean out... broscience? Logic? Or bullshit? It's one of the better-known pieces of broscience: "Nicotine chewing gums will promote weight loss!" Aside from being "better-known", it's yet also highly controversial. In that, people usually don't question the fact that nicotine chewing gums may promote weight loss (we do all know that smokers are leaner, don't we?), but rather that they do so in the absence of significant ill-health effects. Since this is the SuppVersity and not the bb.com bulletin board, I am not going to restrict today's analysis on the health issues. Instead, I will start by looking for scientific evidence that would confirm the common sense assumption that chewing nicotine gums does, in fact, promote weight loss -- in humans, not in rodents (Lupien. 1988). You can find more True or False articles at the SuppVersi...
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Performance Enhancing Gut Microbes - First Study to Show: Having (The Right?) Gut Bugs Doubles Exercise Endurance

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Yogurt & Co are good for athletes. But is this due to the bacteria? As a regular here at the SuppVersity , you are well aware of the far-reaching effects of having the "right" or "wrong" bacteria in your tummy. The claim that having the "right" bacterial make-up in the gut could have beneficial effects on your performance in the gym or on the track is something you should not believe too credulously. If we had a study to prove these benefits, things would be different, though - a study like the one a group of researchers from the National Taiwan Sport University are about to publish in the scientific bible of resistance training, the Journal of Strength and Conditioning Research (Hsu. 2014). In said study which is still available only as an accepted manuscript, Hsu et al. investigated the association of intestinal bacteria and exercise performance in specific pathogen-free (SPF), germ-free (GF), and Bacteroides fragilis (BF) gnotobiotic...
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Intensify Your Training, Increase Your Gains W/ Combined EMG + Regular Training For 30% Greater Muscle Size Gains

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Voluntary & NMES contractions for Monster Quads? You are always looking for new ways to improve your training outcome? Scientists from the Department of Physiotherapy at the University Cardenal Herrera-CEU might have something for you, then. In their latest study, V. Benavent-Caballer, P. Rosado-Calatayud, E. Segura-Ortí, J.J. Amer-Cuenca, and J.F. Lisón tried to elucidate, whether conducting low intensity resistance training in conjunction with  neuromuscular electrical stimulation (NMES) would provide not just an additional growth stimulus, but also corresponding increases in physical performance, muscle cross-sectional area (CSA) and the capacity to perform daily tasks 22 in exactly those subjects researchers will resort to, when they're looking for generous funding for studies the outcome of which is not going to pay off in form of scripts for a new patentable drug: Older adults living in a geriatric nursing home. Want to get stronger, bigger, faster and leaner? Don...
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Macro Ratios & Glucose Management: Eating Lower GI Carbs and Higher Protein Alone is Less Effective in Blood Sugar Normalization Than You May Have Thought

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Macronutrient ratios matters, but food quality does, too. And so do exercise, laziness, sleep, .... the list is endless, so can we be surprised that modulating GI and protein is not helping much? We all "know" that going low(er) carb is good for your blood glucose management, right? Nice! So, we probably don't need studies like the Marleen A. van Baak's conducted only recently, right? I mean, carbs are bad! So why would we even be interested to hear how much the subjects of the Diogenes Study lost on one of four different diets with varying protein content and glycemic index? Or who would want to know what the subjects' 24-h glucose profiles on one out of four diets differing in carbohydrate content by 10 energy % and glycemic index by 20 units during three days. No one would like to know that, right!? In view of the fact that you're still there, I suppose that I was wrong and you are interested in the effects of different marconutrient ratios and type...
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