Androstenedione, Grand Daddy of All Prohormones: Carcinogenic Poison or Non-Toxic Muscle Builder?
I suspect you have already read statements like " prohormones will kill your liver ", "prohormones will give you gyno" and/or " prohormones will induce prostate cancer ", haven't you? Well, Androstenedione is not methylated, so bro-science would tell you that your liver won't take a beating. Yet, all gynecomastia issues aside, what if its not the methyl-group but the prohormone itself that is liver toxic or carcinogenic? A recent study published in the journal of Food and Chemical Toxicology on May 30 2011 ( Blystone. 2011 ) sheds some light onto potential side effects of the "grand daddy of all prohormones". Chard R. Blystone and his colleagues administered "subchronic" doses of androstenedione @ 10, 20, or 50 mg/kg body weight to male and @ 2, 10, or 50 female mice. And they did that for two years . Figure 1: Cancer risk of male F344/N rats after 2 years of chronic exposure t...