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Antihistamines Block Gene Response to Exercise + Impair its Insulin-Sensitizing, Energizing & Hypotensive Effects

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Is all the exercise you do for nothing if you have to take antihistamines? Unlikely, but what appears to be certain is that they have indeed negative effects on the exercise-induced adaptation process that triggers not just increases in insulin sensitivity, but also improvements in blood pressure and mental energy. "An antihistamine is a type of pharmaceutical drug that opposes the activity of histamine receptors in the body," that's what Wikipedia knows about antihistamines. This, and the fact that there are H1-antihistamines and H2-antihistamines, that they target the histamine H1/2-receptors and that they are used to treat "problems" from allergic reactions in the nose (e.g., itching, runny nose, and sneezing) to insomnia... quite the range ;) What Wikipedia does not know, however, is that histamine is "important substance contributing to the normal day-to-day response to exercise in humans" (Romero. 2016a) and that blocking it will also blo...
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Histidine As a Fat Loss Adjuvant? 6% Fat Loss Without Dietary or Exercise Intervention & More Than Half a Dozen Other Reasons Not To Ignore This Essential Amino Acid

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Histidine as a fat loss adjuvant? Laughable? Not for the obese! For lean folks like her? We'll see... If I had to guesstimate the number of fitness enthusiasts who have ever heard of histidine at all, I would say that 50% probably don't even know what it is, while the majority of the lightened ones will re-iterate what the supplement business has been preaching them "You get more than enough histidine, anyway. So don't worry our superior beta-alanine supplement will work even if you don't take additional histidine." Short term studies confirm this notion. It looks as if we usually have more than enough histidine to have it recombine with beta alanine and form carnosine, but long-term studies are missing and let's be honest: How likely is it that an essential amino acid is nothing but a servant to a non-essential amino acid from the 2nd row? Early results: Histidine modulates feed efficiency Actually we could have known that histidine could have ...
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Amino Acids for Super Humans, Part IV - Purported Ergogenics (1/3): Beta Alanine, The New Creatine?

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Image 1: Despite its presence in meat, fish and dairy, it is near impossible to achieve supra-physiological and thus ergogenic carnosine levels without supplemental beta alanine . Beta alanine, unlike l-alanine is one of the "beta-amino acids", indicating that it is neither essential nor proteinogenic , i.e. it is not built into proteins or used in the synthesis of major enzymes. Nevertheless, beta alanine plays a major role with regard to health in general and brain health and muscular performance , particular. Taken orally, as a supplement, beta alanine (BA) has a slight sweet taste to it ( the artificial sweetener suosan is derived from BA). It is highly water soluble and the funny tingles, which can be avoided by either taking it with food or by taking smaller servings (e.g. 5x 800mg for a total of 4g, which would be a reasonable amount for carnosine "loading") multiple times a day, aside, it is virtually side effects free (some people also de...
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