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L-Ornithine an Anti-Stress Agent: Lower Cortisol, Higher DHEA, Better Sleep W/ Only 400mg of Ornithine Pre-Bed. Plus: Mini-Review of Add. Benefits - Burns, Gut Health, etc.

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Stressed? Maybe ornithine can help. Or is this study just a hoax!? Sounds like marketing shenanigan, right? "Lower Cortisol, Higher DHEA, Better Sleep W/ Only 400mg of Ornithine Pre-Bed." Ok, if it was marketing it would probably say "with only 5g of ornithine." I mean, 400mg that's not enough to generate significant revenues - is it? But before we get to the marketing side of things, let's first look at the science, researchers from the Research Laboratories for Health Science & Food Technologies present in a recent paper in the Nutrition Journal , an open-access journal which charges scientists a certain fee for processing their papers. You can learn more about sleep and the circadian rhythm at the SuppVersity Sunlight, Bluelight, Backlight and Your Clock Sunlight a La Carte: "Hack" Your Rhythm Breaking the Fast to Synchronize the Clock Fasting (Re-)Sets the Peripheral Clock Vitamin A & Caffeine Set the Clock ...
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Use Glutamine to Heal the Gut and Hinder Your Gut Bacteria from Eating Away Your BCAA, Arginine and Other Aminos

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Image 1: Don't do this at home. A pig with cannules that have been dug into its digestive tract to study chemical enzymatic and microbial actions ( University of Illinois ) With terms like "the leaky gut syndrome" and the usual quick (and not so quick) fixes a la "solutions for a leaky gut" being all over the blogosphere, I suspect that I am not telling you anything new, when I say that there is reasonable scientific evidence that glutamine is good for your gut (nice alliteration, by the way ;-). That it is yet also "good" for the bacteria in your gut may be news to you. According to a recently published study by scientists from the Laboratory of Gastrointestinal Microbiology, at the Nanjing Agricultural University in Nanjing, China, dietary l-glutamine can exert direct regulatory effects on the amino acid utilization of your gut bacteria - specifically their uptake and use of l-arginine and related amino acids ( Dai. 2012 ). "Hey, you gut ...
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Amino Acids for Super Humans. Part II - Arginine, Citrulline and Ornithine: Nitric Oxide and Beyond

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This relevant for all of you - regardless of whether you can or cannot spare the time: Tune in live and listen to me @ Carl Lenore's Super Human Radio to learn that amino acids are far more than just the building blocks of the proteins of your body... Listen live to SHR @ 12:00PM ET Amino Acids for Super Humans. Part II (update: click here to download podcast ) Arginine, Citrulline and Ornithine: Nitric Oxide and Beyond In the second installment of the show we are going to look at the purported and busted NO Booster l-Arginine, its metabolites citrulline and ornithine, malic acid or alpha ketoglutarate binding of this amino acids and their largely overlooked effects on glucose homeostasis, protein synthesis and detoxification . As usual, I will do my best to provide relevant examples and relate the theory to practical advice. The magic of individual amino acids will be tackled in the shows to come. Update: The show is now available for down...
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L-Ornithine HCL as an Ammonia-Buffer for Hard Training Athletes

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Figure 1: Chemical structure of L-ornithine (HMDB v2.5) Habitual readers of the SuppVersity will be familiar with the ergogenic effects of l-ornithine . A recent study by Demura et al. ( Demura. 2010 ) verified the immediate effect of l-ornithine supplementation on ammonia and glutamate metabolism. In their 14 healthy young volunteers, who trained regularly , the scientists observed significant increases in plasma ammonia and glutamate upon supplementation of 0.1.g/kg body weight before the subjects conducted incremental exhaustive ergometer bicycle exercises. Interpreting their results as follows, although the ingestion of L-ornithine hydrochloride before the exercise cannot be expected to improve performance, it does increase the ability to buffer ammonia, both during and after exercise , Demura et al. are yet reluctant to postulate a direct effect on exercise performance.Such an effect has however already been reported in the 2008 study by Sugino et al. , I already referre...
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L-Ornithine: Arginine's Overlooked Metabolic Child

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Molecular structure of l-ornithine ( HMDB. V2.5 ) Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine. It is a central part of the urea cycle, which allows for the disposal of excess nitrogen. L-Ornithine is also a precursor of citrulline and arginine BUT hardly any of the self-proclaimed supplement gurus know about its proven effects on exercise performance. Almost two years ago, Sugino et.al. ( Sugino. 2008 ) published the results of a study which investigated the effect of 2mg or 6mg l-ornithine supplementation on 120min exercise performance on a cycle ergometer and found that oral L-ornithine administration promoted lipid metabolism and activated the urea cycle from serum triacylglycerol, ketone bodies, free fatty acids, and blood ammonia level changing. L-ornithine significantly attenuated the subjective feeling of fatigue (measured by visual analog scale at postrecovery) compared with postload (P < .01). [...] In the ph...
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