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Androstenedione, Grand Daddy of All Prohormones: Carcinogenic Poison or Non-Toxic Muscle Builder?

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I suspect you have already read statements like " prohormones will kill your liver ", "prohormones will give you gyno" and/or " prohormones will induce prostate cancer ", haven't you? Well, Androstenedione is not methylated, so bro-science would tell you that your liver won't take a beating. Yet, all gynecomastia issues aside, what if its not the methyl-group but the prohormone itself that is liver toxic or carcinogenic? A recent study published in the journal of Food and Chemical Toxicology on May 30 2011 ( Blystone. 2011 ) sheds some light onto potential side effects of the "grand daddy of all prohormones". Chard R. Blystone and his colleagues administered  "subchronic" doses of androstenedione @ 10, 20, or 50 mg/kg body weight to male and @ 2, 10, or 50 female mice. And they did that for two years . Figure 1: Cancer risk of male F344/N rats after 2 years of chronic exposure t...
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The (Re-)Discovery of 17{beta}-hydroxyestra-4,9,11-trien-3-one: Low Dose Trenbolone Safely Promotes Myotrophic Actions in Skeletal Muscle and Provides Partial Protection Against Bone Loss and Visceral Fat Accumulation

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Sometimes it is interesting to see how agents that have been around all along reappear back on the medical scene, all of a sudden. A recent study conducted by a group of scientists from Florida ( Yarrow. 2011 ) that compared the effect of different doses of 17{beta}-hydroxyestra-4,9,11-trien-3-one aka Trenbolone on muscle hypertrophy and prostate health of testosterone seems to have the potential to trigger such a "revival": In both intact and orchiectomized animals, all TREN doses and supraphysiologic testosterone-enanthate augmented androgen-sensitive levator ani/bulbocavernosus muscle mass by 35-40% above Shams (p≤0.001), and produced a dose-dependent partial protection against orchiectomy-induced total and trabecular bone mineral density losses (<0.05) and visceral fat accumulation (<0.05). The lowest doses of TREN successfully maintained prostate mass and hemoglobin concent...
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Potratz on SHR: Grape Fruit Oil for Enhanced Oral Steroid Resorption

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Just for those of you who are not yet addicted to the Super Human Channel , i.e. Carl Lenore 's radio program on exercise, nutrition and longevity: Wednesday, 15 December 2010, Carl had Eric Potratz from Primordial Performance on the show and talked to him about what could be the future of oral drug/steroid delivery. Although the show certainly smacks of a product pimpjob, the general information Potratz provides is scientifically correct. Audio 1: Super Human Radio - 631 - Oral Hormone Delivery And Bioavailability Potratz main argument that grape fruit blocks the intestinal esterase, i.e. the removing of the ester attached to a steroid to render it absorbable via the lymphatic system, has been confirmed in several studies. More recently, Li et. al. ( Li. 2009 ) reported: [..] oral coadministration of GFJ [Grape Fruit Juice] or an esterase inhibitor, bis-( p -nitrophenylphosphate), with the prodrugs led to respective increases in plasma area under the ...
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