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Phenibut, Addictive Sleep Aid With Unhealthy Hangover? Dosages, Effects, Side Effects and Safety Concerns

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Some say phenibut has addictive potential, others say it stops working after only a week and a third group of people will tell you that it's highly toxic and should not be used anyway... What's true? What's bogus? And how likely is it that phenibut helps / hurts you? In a way today's SuppVersity article is part of the reverberations of the last installment of the Science Round Up , where Carl and I have been talking about the non-existent or surprisingly excitatory effects of GABA in certain individuals. I also presented a list of GABA alternatives that ranged from valerian to melatonin - a list of natural alternatives which did for that very reason not include phenibut (also "phenybut"; I will refer to it as "PB" for convenience reasons), a γ-aminobutyric acid (GABA) molecule with an additional phenyl group in the β-position. It is this small, but important structural difference that allows the phenibut molecules to pass through the bl...

Melatonin, Magnesium and Zinc for a Healthy Night of High Quality Sleep

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Sleeping disorders are very common in our hectic society and sleeping pills are among the no.1 drugs (ab-)used by the general public. At least in a very restricted group of subjects, the combination of melatonin , magnesium and zinc has now proven a very viable and certainly more natural alternative to the highly advertised "chemical maces" of the big pharma companies. Figure 1: Effects of treatment of the primary end point. Mean Pittsburgh Sleep Quality Index (PSQI) (marker) are reported at baseline and at 8 weeks for the melatonin, magnesium, and zinc (left) and placebo (right) participants, together with their standard deviations (whiskers). (Figure 2 from Rondanelli. 2011 ) In a double-blind, placebo-controlled clinical trial set in along-term care facility in Pavia, Italy, researchers from the University of Pavia ( Rondanelli. 2011 ) found a combination of 5 mg melatonin , 225 mg magnesium , and 11.25 mg zinc , mixed with 100 g of pear pulp taken 1 hour before bed...
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