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Easy Whey to Prevent LPS Induced Inflammation? Whey Protein Prevents LPS Binding to TRL-4 and IL-8 Production. Surprise: Pressurized Denatured Whey Works Best!

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Unlikely that this or whatever whey protein you have bought as of late was pressurized with an Avure High Pressure Processing System at more than 500mPa in order to denature it (yeah you're reading right) and produce a bunch of fancy new peptides which appear to have even more potent anti-LPS effects than those in regular whey protein (hydrolysate). Saturday's post on saturated fatty acids and their negative effects on post-prandial endotoxemia has turned out to be (un-)surprisingly popular. I am still not sure if this will be same for the post at hand; and that despite the fact that it revolves around the exact same topic, namely the inflammatory reaction to lipopolysaccharides (LPS). In the case of endotoxins such as LPS, the inflammation, which is, as you all should by now be aware of, an endogenous "alert, defense and repair" reaction of our bodies, is actually triggered by their interaction with the so-called toll-like-receptor. Now scientists from the McGi...

Saturated Fat & Postprandial Endotoxemia. Caffeine & Max. vs. Submaximal Exercise. Lactoferrin & the Battle Against Visceral Obesity. High Intensity Strength Training, Free Testosterone & the Use of Perceived Recovery Scales

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Gram negative bacteria, as these E. coli bacteria which have been photographed with a low-temperature electron micrograph (magn. x10,000) tend to produce endo toxins in your gut, while gram positive bacteria tend to produce exo toxins on your food - nasty, ha? It has been estimated that a single cell of Escherichia coli contains approximately 106 Lipid A or endotoxin molecules with a mass of about 1 00,000 Da (the exact mass varies according to the LPS type). The typical human intestinal tract can harbor approximately one gram of endotoxin, which is ~2-4x more than what scientists used in previous rodent studies as a "lethal dose" (Kawai. 1991). Aside from the information about the lethal dose of endotoxins in rodents, these figures, which are at the same time the SuppVersity figures of the week are part of the study by Mani et al. with which we are going to kick off this week's installment of On Short Notice . I guess these figures give you an idea of the toxic p...

Yohimbine & Berberine Protect From Death Due to LPS Intoxication; BCAAs Inhibit Serotonin Metabolism & Cause Anxiety, Tryptophan but not SSRIs Help; Sweet Tea Leaves Are PPAR-G Antagonists & Battle High Lipid + Leptin Levels

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Skip the fireworks invest the money in some quality ingredients for a fondue or whatever you like and invest the (often non-negligible) rest of the money in a gym membership for the next year. Actually my figure of the week is 115,000,000 EUR (~152,000,000 US Dollar), which is the sum my fellow country men and women are about to waste on pyrotechnics this year. And a scientifically unconfirmed addition based on my personal observation: 90% of the worst offenders as far as spending money for fireworks goes are at least overweight. Would be interesting to see, if the use of pyrotechnics on New Years Eve is directly associated with fat mass... I mean, it could be that they spent so much money on their fireworks that they feel they can only afford the junkfood of which everybody and his/her mama still tend to believe that it would be cheaper than buying fresh products and preparing your own food from those. Ah, I am ranting. That's usually Carl Lanore 's task, so I will bet...

Mercury, From Fish to Toenail; Less Testosterone Needed W/ TRT + Tongkat Ali; R,R-Monatin the Next Stevia From South Africa! Plus: Magnesium Protects Mitochondria from LPS & Caffeine Arteries from HIIT Induced Platelet Activity!

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Image 1: Looks like the Terminator was concerned about "bone" health, maybe he should consider Tonkgat ali as an addition to his TRT... or whatever regimen;-) If you want to, you can call today's news a special installment of " On Short Notice " , I have already had a couple of interesting news and before I am piling up another truckload, I thought I could make at least some of you happy and put a handful of them out before the Super Human Radio & SuppVersity Science Round-Up on Thursday (you better make time to listen live , Thursday, 12PM/EST and download the first installment if you haven't done so, already ;-) and the "official" Saturdaily installment of " On Short Notice " , here at the SuppVersity . So let's see what we have here: Contrary to the order in the headline we will check out your toenails later, after all, I don't know what they look like and don't want to kill your appetite so that you cannot f...

Something Fishy: Leucine-Rich Protein + Fish Oil Supplement Boosts White Blood Cell EPA Content and Immune Response

Regular readers of the SuppVersity, as well as people who religiously follow Carl Lenore's Super Human Radio and happened to listen to my 1st appearance on the show, will know that I am generally skeptic about the usefulness of unwarranted high dose (>1-2g of combined EPA + DHA) fish oil supplementation. This is not because I think fish oil is poison, but rather out of my awareness that its pharmacological effects have more similarity to those of a drug than to those of a "common food" (including possible side effects). Now, a group of scientists from the Netherlands and the United Kingdom published the results of a study ( Faber. 2011 ) which found another interesting stone from the fragmented mosaic our current understanding of the effects and nutritional interactions of fish oil, in general, and EPA, in particular, resembles. While the aim of the study, which was to quantify the incorporation of EPA and DHA into white blood cells, was nothing new, the nutritional ...
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