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The Insulin / Glucagon Ratio and Why Diabetics and People W/ Severe Insulin Resistance Must be Careful With Protein

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You're insulin resistant and trying to lose weight with high protein intakes? Then you got to read this article carefully... High protein diets can help you lose weight while maintaining muscle mass. This should make them the ideal choice of diabetic patients, many of whom are suffering from weight issues that are often not corollary, but rather causatively involved in the development of type II diabetes. Unfortunately, studies in type I diabetics and preliminary evidence from type II diabetics and other insulin resistant individuals suggests that - if the disease has progressed significantly - eating too much protein can be a problem, as well, one that may worsen the ill effects of diabetes. Having high amounts of protein after  fasting  may ruin your glucose levels?! Breakfast and Circadian Rhythm Does Meal Timing Matter? Habits Determine Effects of Fasting Fasting Works - It Does, Right!? Does the Break- Fast-Myth Break? Breakfast? (Un?) Biased Re...
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GABA Supplementation Improves Glucose Management - Even in Healthy Subjects | Significant Reduction in Glycated Albumin Levels After Only 7 Days on 3x2g GABA per Day

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No acute changes in blood glucose, but extreme changes in insulin levels. How can this trigger a reduction in glycated albumin - How's that possible?  You've read about gamma aminobutyric acid (GABA) at the SuppVersity  before. While most people think of it mainly as a calming agent, though, SuppVersity  readers know that it has the remarkable ability to heal the insulin producing β-cell in rodents by stimulating their replication, protecting them against apoptosis, and attenuating insulitis (Soltani. 2011; Tian. 2013; Prud'homme. 2014; Purwana. 2014). And while these favorable effects were first observed in mice, researchers are quite sure that they are valid in humans, too- that's also because said effects have been confirmed only recently by Tian et al. (2014) and Purwana et al. (2014) in vitro as well as in xenotransplanted human islets. Learn more about the effects of GABA & co at the SuppVersity GABA Diabesity Treatment Phenibut Addic- tive ...
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Whey and Casein Work Hand in Hand for Protein Anabolism, but Scientists Overlook Fat, When They Reassemble Milk

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Image 1: Ex-Mr. Universe, Manohar Aich, turns 100 and swears by milk and other whole foods ( NYDaily ) Do you know the good old saying that you often only realize what you had, once you have lost it? A recent study by scientists from the Division of Endocrinology at the Mayo Clinic in Rochester ( Soop. 2012 ) is only the latest instance, in which we (in this particularly case not even scientists, but the food industry) disassembled a natural product, namely milk, in order to maximize its benefits (or our revenues?) only to realize now that the the resulting parts - as good as they may be - are not up to what the whole has had in stock for us. Whey + casein + lactose = almost milk In order to quantify the quantity and time course of the total body, splachnic (hepatic) and leg protein flux of whey and casein, Mattias Soop, Vandana Nehra, Gregory C. Henderson, Yves Boirie, G. Charles Ford, and K. Sreekumaran Nair conceived a clever experiment. They used differently labeled whe...
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L-Ornithine: Arginine's Overlooked Metabolic Child

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Molecular structure of l-ornithine ( HMDB. V2.5 ) Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine. It is a central part of the urea cycle, which allows for the disposal of excess nitrogen. L-Ornithine is also a precursor of citrulline and arginine BUT hardly any of the self-proclaimed supplement gurus know about its proven effects on exercise performance. Almost two years ago, Sugino et.al. ( Sugino. 2008 ) published the results of a study which investigated the effect of 2mg or 6mg l-ornithine supplementation on 120min exercise performance on a cycle ergometer and found that oral L-ornithine administration promoted lipid metabolism and activated the urea cycle from serum triacylglycerol, ketone bodies, free fatty acids, and blood ammonia level changing. L-ornithine significantly attenuated the subjective feeling of fatigue (measured by visual analog scale at postrecovery) compared with postload (P < .01). [...] In the ph...
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