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Conjugated Linoleic Acids: What's the Difference Between cis-9,11 and trans-10,12 CLA and Should We Label Them as "Transfats"? Plus: What Makes CLA Potentially Harmful?

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If Hayden Panettiere drinks it dairy can't be bad - despite (or because?) CLA, right? Well, what if I told you that Mrs. Panettiere was advertising milk in the "Got Milk" campaign despite being lactose intolerant? As a SuppVersity veteran you will be familiar with the idea that trans-10, trans-12 conjugated linoleic acid is the "fat burning" CLA isomer, while 9 cis,11 trans linoleic acid appears to blunt some of the pro-inflammatory actions of its cousin and has been shown to have specific physiological effects on it's own (e.g. increased bone health, cf. Platt. 2009; anti-cancer, cf. Corl. 2003). As I already mentioned, this is probably nothing new for you, if you make sure to get your daily dose of SuppVersity wisdom everyday. What you may however not be aware of is the fact that researchers like Ye Wang and Spencer D. Proctor are - despite the never-ending hoopla around potential weight loss effects of CLA - still contemplating, whether CLA could ...
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Maintain & Increase Your Insulin Sensitivity - Wrap-Up: Overview + 3 Stacks. Plus: AMPK & PPAR-γ Revisited

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It's not about exercise or nutrition, it's about both of them. And as long as it is not about the former it should not be about supplements either. It's Sunday and finally time for the wrap up of the "Maintain & Increase Your Insulin Sensitivity" Series ( read all previous installments ). It took me quite some time to get through all the compounds on my and your list and the outcome is far from being a "complete" list of all the agents that can have beneficial effects on your insulin sensitivity. Still, if there is at least one agent, one fact or one take home message for each of the 6 previous articles of which you would say: "Ok, I guess that was worth wasting some of my valuable time on", I would be happy. For myself it was by the way yet another occasion to learn more  about many of the agents, I reviewed in this series . And if you listened to the SuppVersity Science Round-Up on Thursday , you will probably remember that I said...
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The Quest For the Best N6:N3 Ratio. Swine Study Suggests: 5:1 is Healthy, 1:1 Will Also Cut Fat and Build Muscle

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 Yes, this study is about omega-3s, but it is not about the beneficial effects of fish oil. Ok, I see you are totally excited, so I am not going to beat around the bush for long: According to a soon-to-be-published study from the Hunan Provincial Engineering Research Center of Healthy Livestock, Institute of Subtropical Agriculture at the Chinese Academy of Sciences  a 5:1 ratio of n-6:n3 (as in omega-6 to omega-3) is good enough to keep pigs healthy. Kicking out another couple of grams of omega-6 fatty acids, on the other hand, had pretty intriguing effects on the body composition of the ninety-six male cross-bred (Large White£ Landrace) pigs who happened to weigh about as much as an average human being (another advangate, of swine - HED calculations are not necessary; learn more ). Did you know that pigs are opportunistic omnivores just like us and provide a better model of human metabolism than our little, furry remote cousins with the big round eyes and the lo...
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Fighting to Stay Lean? These 20+ Anti-Obesity Agents Have the Potential to Inhibit Fat Gain Right at the Cellular Level

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No, none of the 20 agents in the list below is going to do the work for you, but they could help you "conserve" the results, keep you lean on a bulk and/or avoid the hazardous Yoyo effect when you go off a die. It's actually normal that the introduction is the last part of an article I write. What's special about today's SuppVersity article is thus not that I write the introduction at the end, but that I did not really know what I would be writing here, when I set out to compile the unsorted (but not chaotic) list of potential anti-obesity agents below. All of them act by pathway(s) you as a SuppVersity reader will have read about before, most prominently AMPK , and the peroxisome proliferator receptors (PPARs), of which the blockade of the obesogenic PPAR-gamma pathway, which is the main working principle of CLA turned out to be the go-to explanation for the ability of these agents to block both the differentiation of adipocytes and the storage of tr...
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20 Weeks of Gluttony Without Gaining a Single Gram of Visceral Fat? A Water Extract From Hops Made It Possible

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Hops: More than an ingredient of the majority of OTC sleeping pills (photo LuckyStarr) Hops beer made from the female flowers of Humulus lupulus was the (safer) alternative to untreated water in medieval Europe. Hops are the female flowers (also called seed cones or strobiles) of a hop species and are currently still used as a flavoring and stability agent in beer. Aside from that, the vigorous, climbing, herbaceous perennial has a longstanding history of medical uses and is probably best known for its sedative effects. That a hot water extract from hop could make an excellent addition to an anti-obesity and even fat loss regimen is yet news and - in view of its efficacy - even SuppVersity news ;-) Eat like a pig, look like a goddess with hops! Actually the subheading is pretty unfair, after all pigs don't eat much different from us, they are opportunistic omnivores... but this is no biology lesson, so let's get back to the topic at hand. There was a time, when I thou...
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Seabuckthorn Leaves Increase PPAR-Alpha & PPAR-Gamma Expression, Keep the Liver Fat Free and Fatty Oxidation Up. Plus: PPARs - High or Low? How Are They Supposed to Be?

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This time, the magic is in the leaves, not the fruits or kernels. And it's dose dependent. With an almost linear increase from 500-1,000mg/kg Honestly, I don't think that it is coincidence that many of the most promising medical plants are shrubs that live on barren soil, like sand dunes and cliffs and are full of thorns as well as innate polyphenolic defense mechanisms. Whatever the "evolutionary" basis may be, if we go by the beneficial metabolic effects, researchers from the Department of Food Science and Human Nutrition at the Chonbuk National University in the Republic of Korea, it appears worth going through all the traditional used folk medicine across the world and identify which of them work, how they work and whether they may already have what it takes to get rid of one or the other of the typical Western diseases. In the case of the ethanolic extract of seabuckthorn ( Hippophae rhamnoides L ) Pichiah et al. used in their most recent experiment, this...
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