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DHEA Inhibits Fat Gain More Effectively Than Testosterone. Both Work by Reducing PPAR-γ and Thusly Lipid Storage

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Image 1: This is the "Fountain of Youth" in Karlsruhe, Germany. I have never been there, but I guess I should take the next train and check whether water contains 0.4% or 0.8% DHEA ;-) Outside of the medical practices of some anti-aging docs nobody appears to care about the "good old" dehydroepiandrosterone (DHEA), these days. As a diligent student of the SuppVersity, you are yet well aware of the reviving effects DHEA has on the liver (cf. August, 26, 2011 ), pancreas & insulin sensitivity (cf. May, 15, 2011 ) and adipocyte metabolism (cf. April, 8, 2011 ) in "older" people or everyone with suboptimal DHEA levels. You will also be aware that the adrenal steroid hormone which can be converted to testosterone (and thusly DHT or estrogen) at the target tissue exerted pretty astonishing effects on body composition in a handful of initial (very) high-dose trials. Follow up studies in the late 1990s were yet mostly unable to reproduce these encouraging...

Biotin Ameliorates Skeletal Muscle Insulin Resistance in Model of Type II Diabetes. Increase in GLUT-4 Expression Yet not Accompanied by Translocation to Cell-Membrane

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Image 1: Otsuka Long-Evans Tokushima fatty rats (OLETF, right) have the genetical disposition to become type II diabetics. Are your nails brittle? Is your hair falling out? No? Then, are you obese or insulin resistant? Yes? ... I guess, by know you are asking yourselves what your hair and nails have to do with your pre-diabetic beer-belly. Well, according to the recently published restults from a study by Yuka Saki and his Japanese colleagues, biotin, the water-soluble nutrient that has been discovered by Bateman in 1916 and is also known as vitamin B7, vitamin H or coenzyme R could well be the missing link. After all, the well-known, but often misunderstood micronutrient plays a central role in both fatty acid, as well as glucose metabolism and is by no means just a "hair & nails" vitamin. Biotin could help even if "it's in your genes" ;-) The Japanese researchers used the infamous Otsuka Long-Evans Tokushima fatty rats whose name already implies t...
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