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Sucralose: Study Seems to Confirm Pro-Diabetic Effects (-18% Reduced Insulin Sensitivity in 2 Weeks) of Realistic Amounts of Sucralose in Humans - What's the Verdict?

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What's the verdict on sucralose? You will have read it in the SuppVersity news on Facebook ( Sunday, September 16, 2018 ): Scientists from the  Unidad de Investigación en Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán  in Mexico City are the first to present  somewhat convincing evidence that the insulin sensitivity of healthy individuals can deteriorate (at least transiently) within only 14 days of consuming a high but realistic amount of sucralose (2.25mg/kg total) with every of your three main meals. Today, sucralose, which has been pulled from the diet drinks of the biggest players in the beverage industry, i.e. Pepsi and Coke (allegedly because people didn't like it - conspiracy theorists listen up ;-), is still used in selected diet drinks, diet sodas, flavored iced teas, fruit-flavored waters, hot chocolate, as well as various sweetened condiments, dairy products, chewing gums, candy and your supplements ...
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Sweeteners in the Real World: 12% Increase in GLP-1 and Non-Significant Effects on Insulin W/ Diet Soda From Well-Known Brands and Seltzer + NNS Control - Implications?

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Drinking diet soda now and then is certainly not going to harm you. Everyone knows that "[n]on-nutritive sweeteners (NNS), especially in form of diet soda, have been linked to metabolic derangements (e.g. obesity and diabetes) in epidemiologic studies" (Sylvetsky. 2016). What only SuppVersity  readers know is that experimental evidence to prove that the associations between obesity and artificial sweetener consumption from epidemiological studies is not the result of reverse causation, i.e. obese / overweight individuals gravitating towards the consumption of non-nutritively sweetened drinks in the false belief that this alone would help them to lose weight does not exist. You can learn more about sweeteners at the SuppVersity Aspartame & Your Microbiome - Not a Problem? Will Artificial Sweeteners Spike Your Insulin? Sweetened Drinks Beat Water as Dieting Aid Chronic Sweeten-er Intake Won't Effect Microbiome Sucralose Tricks 'Ur Energy Gau...
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Sucralose: Sweet Taste / Energy Content Mismatch Offsets Our Nutrient Gauge and May Make us Overeat, but...

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Beware: Splenda(R) is not sucralose, but 95% dextrose (D-glucose) and + maltodextrin combined with an undisclosed small amount of mostly indigestible sucralose. "These findings further reinforce the idea that 'sugar-free' varieties of processed food and drink may not be as inert as we anticipated. Artificial sweeteners can actually change how animals perceive the sweetness of their food, with a discrepancy between sweetness and energy levels prompting an increase in caloric consumption," Professor Herzog said according to the press release the University of Sydney published last week alongside the publication of a study that was co-authored by Herzog in CELL Metabolism - a study with the telling title "Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response" (Wang. 2016). You can learn more about sweeteners at the SuppVersity Aspartame & Your Microbiome - Not a Problem? Will Artificial Sweeteners Spike Insulin? Sweet...
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Can Stevia Help You Ward Off Type II Diabetes? A Review

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Unfortunately, it is not even clear if you need the "white stuff", i.e. pure steviosides, whole leaves of leaf-extracts to maximize the anti-diabetic effects of stevia. What is clear, though, is that there's still a lot of research to be done. "Can Stevia Help You Ward Off Type II Diabetes?" That's not just the title of today's SuppVersity  article, it is also the research question of a recent paper by Esteves A.F. dos Santos from Farmácia Progresso  (dos Santos. 2016). An interesting question with an obvious answer: if you replace  sugar in your diet with stevia, it will help. Now, you know that this would not be worth discussing in a SuppVersity  article of its own. What is  worth discussing, though, is that stevia contains "compounds and other substance obtained from stevioside hydrolyses" (dos Santos. 2016) such as isoteviol  of which studies show that they can be used as 'active' diabetes treatments - meaning: they help, eve...
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