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ALA, Berberine, Metformin, Resveratrol, AICAR & Co - Are AMPK Mimetics & Activators Good or Bad for Athletes?

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Unless you're planning to just sit, instead of cycle on your spinning bike, it is by no means sure if your performance well benefit or maybe even suffer from the use of AMPK mimetics and activators. Recently someone asked me on Facebook, whether AMPK activators like Lipoic acid (ALA), Berberine, Metformin, AICAR & Co wouldn't make excellent performance boosters. I pondered that question for some time and said: "If you are about to compete in a highly glycolytic sport, the opposite is probably the case." There's little question that supplements like lipoic acid are useful if you are an overweight type II diabetic. But let's be honest: How many of you fall into this category? As healthy, active individuals or even athletes, on the other hand, you should be aware that the ability of these agents to increase the glucose uptake and block the glyconeogenic pathways in the liver may easily make you run out of fuel during anaerobic activities like lifting or...
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When Timing Matters - Alpha Lipoic Acid: Works Best, When it's Taken 30min Before a High Carb Meal. Can Easily Make You Hypo, if You Forget the Carbs or Have it on Empty

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A salad like the one the beautiful young lady is about to eat is not the kind of meal that would require pre-meal lipoic acid supplementation. Although I am not convinced that alpha lipoic acid (lipoic acid aka ALA) will actually partition glucose preferentially to muscle, because studies indicate that it will increase glucose uptake in fat cells, as well (and that at 10x higher glucose transporter expressions in fat vs. muscle cells; Estrada. 1996; Konrad. 2001), there is still good evidence that it can help people with (full-blown) insulin resistance stash away the glucose they consume, more effectively. To do so, it would appear logical that alpha lipoic acid has to be consumed in the vicinity of a meal. The question I am trying to answer today is thus: When do you have to take your alpha lipoic acid to ensure optimal glucose "repartitioning"? Learn more about the effects of your diet on your body composition at the SuppVersity Ladies, Beware! Dieting Makes G...
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Circadian Clock Normalization as Novel Mechanism Behind the Health Benefits of ALA in NAFLD & Diabesity | Plus: ALA For Athletes & the Obese - Yes/No + When to Take It?

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Yes, you can buy alpha lipoic acid as bulk powder, but if you still have intact mucosa and want to keep it intact, I suggest you swallow pills. Alpha lipoic acid aka "ALA" is a natural AMPK agonist that works similar to metformin. Developed by BASF and others as an anti-diabetes medication in the late 20th century, it's now a popular supplement that is prescribed as a "drug" to type II diabetics only rarely and only in Europe, yet not in the US. Based on the currently available evidence its anti-diabetic effects are comparable but far inferior to metformin. In view of the fact that lipoic acid is also non-patentable and thus not exactly profitable, it's no wonder that it has disappeared from the radar of the medical establishment over the past decade. Learn more about lipoic acid here at the SuppVersity ALA Boosts Creatine Uptake ALA + More vs. Migraine What's the Best N3:N6 Ratio? High EAA protein for fat loss ALA = Nutrient-Re...
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Supplemental NAFLD (Non-Alcoholic Fatty Liver Disease) Protection for Everyone! Regular Alpha Lipoic Acid (300mg) & Vitamin E (700IU) For Less Than $20 Do the Trick!

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You don't have to look at the liver of this person to know that he / she is suffering from NAFLD - just like an ever-increasing minority (soon majority) of US citizens You may asking yourselves what "looking good naked" has to do with obesity and diabetes right now, but if you think about it, the things you have to achieve the one (don't tell me you don't care if you look good naked, liar!) and avoid the others are actually not too different and what's commonly overlooked: The liver is of pivotal importance for both! Looking healthy and being healthy. In spite of the fact that I am going to get back to the "liver <> diabetes" connection later in the article, I would like to invite you to take a closer look at a previous article on that topic "Liver Enzymes the #1 Marker of Insulin Resistance!? Plus: What Does the Correlation Bettwen HbA1C & ALT, AST and GPT Tell Us About Diabesity?" to catch up ! You can learn more about ...
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Alpha Lipoic Acid, GABA, Taurine, Green Tea, Gooseberry & Fenugreek. Plus: Metformin the No.1 Drug? Supplements to Improve and Restore Insulin Sensitivity - Serving #1

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Don't forget, those caps and pills are not worth a penny without you committing to the all the lifestyle changes I outlined in episode one of this series . I am well aware that you had to wait for a full week for this 2nd part of the "Restore & Maintain Insulin Sensitivity" Series ( read part I ), so I am going to make no words about it and get straight to the annotated list of useful supplements. Just a reminder for the lazy asses: Don't even think about starting any of the supplements on the list, if you have not already cut your carbs to a low, but not very low level, got rid of all plain sugar in your diet, started to work out frequently , get enough sleep, avoid stims and control (not totally eradicate) your linoleic acid (omega-6) intake. Here we go, for serving #1 In order to give you at least some guidance on where you may want to start, I will classify the supplements in 4 very broad categories with [A] for supplements that are almost certai...
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