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Green Tea Dose-Dependently Sheds 7%-20% Body Weight in Mouse Model, But Higher Doses Turn Out to Be Pro- not Anti-Inflammatory In Recent Tufts Study

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Image 1: A cup of freshly brewed green tea (photo by Wikimol ) Green tea is healthy, it gets you going, will make you lose fat and calm down inflammation ... wait ! Is it possible that all that was just another marketing scam? Scientists from the Tufts University in Boston (Pae. 2011) have now found that at least in case of the capped green tea extracts, health (over-)conscious GNC-consumers are popping like candy, these days, the latter, i.e. the anti-inflammatory effect is absent. And, it even gets worse, higher doses of a standardized EGCG extract (TEAVIGO; 95% EGCG content) even increased inflammation (measured via proinflammatory cytokines in the blood of the animals) in a group of 6-9 months old pathogen-free male mice who had been fed a diet enriched with 1% of the extract for 6 weeks: Contrary to the assumption that EGCG would reduce inflammatory response, mice fed 0.15% and 0.3% EGCG diet exhibited no change while th...

Ask Dr. Andro: What Are Human Equivalent Doses (HED) and How Do I Calculate Them?

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Image 1: Rat & guinea pig. Both very popular animal models. Both about the same size and weight, but with very different reactions to identical treatments. I won't waste too many words on this being a new series on the SuppVersity , I suppose the name "Ask Dr. Andro" is self-explanatory. It is based on questions posted in the comment section that are relevant for the majority of the visitors and require and deserve a more sophisticated response. So, if you want your question answered, learn a lesson from "Learner" who posted the following question in the comment section of " Spicing Up Fat Loss: Structural Similarity to Melanocortin-4 Agonists Powers Piperine's (Black Pepper Extract) Fat Loss and Lipid Lowering Effects ". Question from "Learner" : Why is the mg/kg dosing ratio different for humans than rats, and does that vary by the agent? Answer from Dr. Andro : Most of what we know about the effects of (new) drugs, ...

Leptin & AMPK Activation in Muscle - Did Scientists Investigate the Wrong Species?

Actually, this is something I have been reminding people of for years: Human beigns are no mice and although some people may be rats, genetically they are still very different. Usually I put this argument forward if anyone presents me with a study done on rodents that "shows" how bad dietary protein, especially from meat, is for you - thin of it: when was the last time you saw a mouse eating a cow? This time the issue is a little more sophisticated, though... Australian scientists ( Laker. 2010 ) have recently investigated the effect of leptin on AMP-activated protein kinase (AMPK) in muscle of sheep and (I do not know if to their, but maybe to some of the proclaimed experts surprise) they found that... [...] leptin infusion reduced (P<0.05) food intake and body weight and it also increased plasma adrenaline concentration at 6 h and 7 days, suggesting increased sympathetic nerve activity. Despite this, and in contrast to rodent studies , central leptin infusion did not...
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