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High Fructose Consumption, Inflammation Up (Bad), LDL-to-HDL Ratio Down (Good) - Is That Good or Bad for the Heart?

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Remember: If anything fructose from beverages (including juices), yet not fructose from whole fruit is a problem. In fact eating whole fruits will decrease your blood lipids and high sensitivity C reactive protein (hs-CRP) inflammation markers. Fructose is bad for you, right? Right. According to the latest study from the University of Newcastle , the consumption of only one drink containing containing 50 g of either fructose or glucose or sucrose dissolved in water will have detrimental effects on the #1 indicator of whole body inflammation, which is high sensitivity C-reactive protein (hs-CRP). Much to the researchers surprise, though, the same amount of fructose had significant beneficial effects on the plasma lipid levels of the healthy male and female adults (n = 14) between the ages of 18-60 years who were recruited by advertisement and underwent study procedures at the Nutraceuticals Research Group Clinic rooms at the University of Newcastle in Australia. Learn more a...
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Blocking Inflammation is Like Choking the Fire: Long Term Weight-, Visceral- and Android-Fat Gain in Human Study Emphasizes Essential Role of TNF-α in Metabolic Control

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Can cooling down the inflammation make your belly grow!? (Mito-)Hormesis and the important and beneficial role of "inflammatory" cytokines, molecules etc. are one of my favorite topics. It's simply intriguing that health, performance and longevity apparently depend on the presence of a healthy amount (whatever that may be) of inflammation. Even the provision of low dose arsenic does not - as you may expect - shorten, but prolong the lifespan of several common model organisms (Schmeisser. 2013). Findings like these don't just conflict with common sense, they are also in opposition to the still prominent free radical theory of aging and it's central message: Oxidation and inflammation are bad for you! No matter what!  Too little is just as bad as too much Most of you will remember one of my previous articles on (mito-)hormesis - if if that's not the case, I'd recommend you start with the "Inflammation is a True Fat Burner" article ( re...
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No Pain no Gain? What Can We Learn From the Time Course of Muscle Damage After Eccentric Workouts. Plus: What's that Got to Do W/ Your Doctor Sending You to the ER

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Concentration curls are among those exercises, where eccentrics can easily be incorporate. Plus. As the EMG Series shows, this increases the biceps activity by almost 50% compared to the regular barbell curl ( learn more ). But will it also make you grow faster? Just let me get this straight right away: I am well aware that it is still debated if and if so to which extend skeletal muscle damage affects or even determines the training induced gains in strength and/or lean body mass and it is not my intention to rekindle this never-ending debate. At least in my humble opinion, it does yet appear that a certain degree of "damage" is necessary for "optimal" gains. Anything that passes this threshold is however, as Schoenfeld points out in what I believe is the most recent review of the literature, not going to "further augment muscle remodeling and may in fact interfere with the process" (Schoenfeld. 2012). The potential of negative interference is obvi...
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Science Round-Up Seconds: Cytokine Modulating Power Cakes, Endurance & Resistance for Maximal Cardiovascular Benefit, Gluten Degrading Bacteria and Cancer Fighting Green Tea + Levitra Combo. Plus: Sirt-3 & Protein Blends

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Not sure if the "Power Cakes" in the Kerasioti study looked like these, but it would sure have been appropriate, after all the poor study participants had to cycle for 3h (in total) - makes you wonder if they are WADA approved, doesn't it? Today's installment of the SuppVersity Science Round-Up Seconds has some delicious stuff for you in stock. We will start out with an interleukin 6 & 10 modulating CRP reducing cake from Greece as an appetizer, or pre-workout, whatever you like better. When we have finished that one, the table or gym talk will center around debunking the myth that only aerobic training was good for your cardiovascular system. When even the last i**** has gotten that, it's about time to devour the delicious anti-carcinogenic and gluten destroying bacteria stew with green tea and Levitra(R), I've been cooking for ya ;-) Before you go for the cake, however, I want to apologize that I was somewhat out of it on yesterday's show ( cl...
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Intermittent Thoughts on Intermittent Fasting - The Fast #2: Health & Longevity Effects of Intermittent Fasting

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Image 1: Any roundworms reading this? I hope you know that by not eating enough and feeling miserable you can extend your lifespan ;-) Thanks Caenorhabditis elegans , or "C. elegans", almost everybody who is able to read a newspaper or online magazine will have heard of the miraculous effects of calorie restriction and fasting on longevity (of this worm!). Since I assume that you possess more gray matter than this transparent nematote, you will probably have asked yourself how, or rather if these results from a worm with an average lifespan of 2-3 weeks translate to human beings,... well, all I can tell you is that leading a miserable life of lifelong dieting appears to work in non -human primates, as well ( Kemnitz. 2011 ). Now, the obvious question is: How does all that relate to Intermitent Thoughts on Intermittent Fasting ? Obviously, none of the roundworms or rhesus monkey's followed Martin Berkhan's intermittent fasting approach, did they? No, I have not ...
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- 66% Body Fat! 7 Weeks of Intense (!) Exercise and Moderate (!) Caloric Restriction Transforms Biggest Losers into Healthy Winners. Improvements Persist 4 Month After.

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Image 1: Coming soon on NBC - the next season of the Biggest Loser; this time big couples I don't know if you have followed the 'Biggest Loser" TV show. Other than the show itself, which I obviously must have missed (I still wonder how that could happen ;-), the recently published study ( Ashmadi. 2011 ) on the effects combined intense exercise and moderate caloric restriction had on the 17 sedentary, morbidly obese contestants (32+/-11 years; 50/50 men/women) , of which 3 were excluded from the study, because their arteries were not yet VERSTOPFT enough, really got my intention. After all, finally someone got the order of the words "intense" and "moderate" in relation to exercise and caloric restriction right... its no longer about starving yourself and walking from the couch to the refrigerator, when your weight has gone up into regions (>>300lbs+), where no man, god-beware woman, had gone before (I guess the introduction of high fru...
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Epidemiological Study Shows Correlation Between Anti-Oxidant Intake and C-Reactive Protein & Homocystein

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After a sudden onset of discussions around the beneficial or even detrimental effects of vitamin supplements in general and antioxidants in particular in the mid to late 2000s, vitamins and, even more, other anti-oxidants have been put back on the map, lately. A recent epidemiological study from the University of Connecticut ( Floegel. 2011 ) provides further evidence for the hypothesis that, after all, consumption of adequate amounts of vitamins C and E , beta carotene , flavonoids and selenium would be beneficial to your overall health Intakes of vitamins C and E and carotene were inversely associated with the probability of having serum CRP concentrations >3 mg/l in multivariate logistic regression models. Flavonoid and Se intakes were not associated with the odds of elevated serum CRP concentrations. The mean plasma Hcy concentration was 8·61 (95 % CI 8·48, 8·74) μmol/l. Intakes of vitamins C, E, carotenes and Se were inversely associated with the odds of plasma H...
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