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Cyclists & Asthma? ~20% Increased Protein Synthesis W/ Salbutamol, Another Reason its Abuse Cannot be Ignored

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Even if it is medically indicated, there's more and more evidence that using beta-2-agonists (esp. but not exclusively orally) could provide an unfair advantage to athletes: increased protein synthesis, increased mitochondrial neogenesis, established ergogenic effects,... If you've been following the news, you will be aware that the Tour de France Champion, Chris Froome, has been busted with elevated levels of the beta-2-agonists  Salbutamol  in his blood ( learn more ). Now, we could debate forever about whether the green light Froome just got is a case of double-standards or not, but that's not the purpose of this article, anyway. Rather, I want to explain why the claim that salbutamol, officially an asthma medication, wouldn't be a worthwhile doping agent is bullshit. Learn more about Clen - / Albuterol  and safer ways to get jacked at the SuppVersity Albuterol Can Improve Glucose Metabolism The Myostatin <> Clenbuterol Connection Higenamine Use...
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β2-Agonists Build Muscle: Low Dose Terbutaline Adds 1kg (DXA) in 4 Weeks - With and Without Resistance Training

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Who would have thought that? Asthma-sprays probably beat the crap out of good old clenbuterol tabs when it comes to building muscle - even if you don't train! Have you ever wondered why so many poor athletes suffer from asthma? Well, if you read my old article about the effects of clenbuterol on myostatin  it may long have dawned on you that this could be due to the muscle-building effects of β2-agonists - doping on prescription, so to say. A couple of days ago, a group of Danish researchers confirmed your suspicions. They'd investigated if inhaled beta2‐agonist, terbutaline, alters body composition and metabolic rate with and without concurrent exercise training in healthy young men. Learn more about Clen - / Albuterol  and safer ways to get jacked at the SuppVersity Albuterol Can Improve Glucose Metabolism The Myostatin <> Clenbuterol Connection Higenamine Useful "OTC Clenbuterol"? Out of question: β2-Agonists = Doping Agents Battle the ...
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Science Round-Up Seconds: PGC-1 Alpha 4 Unlocks Muscle Growth, Alpha Lipoic Acid & Dietary N-6 Overload, Aspirin & Other NSAIDs Your Liver & Overall Mortality

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Myotubes under the microscope - vehicle (top, normal size), clenbuterol (+100% protein content, middle), clenbuterol + PGC1a4 inhibition (+50% protein content, bottom) Actually I would hope that you have by now already listened to yesterday's installment of the SuppVersity Science Round-Up . If you did, you are one of a group of highly privileged trainees who already knows why not all PGC1-alpha is created equal and how the alpha-4 isoform does appear to be the missing link between myostatin, on the one hand, and IGF-1 on the other. If you have already listened to the show, you may also have noticed that I was pretty excited about the publication of the Ruas paper (Ruas. 2012). Firstly this study has almost everything you could expect from cutting edge science: A in-vitro tudy to elucidate the basic mechanisms, an in-vivo rodent study involving both wild-type and genetically modified mice and - much to my own surprise - an in-vivo exercise part. And secondly, the results provi...
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Chronic Albuterol Treatment Improves Glucose Uptake in Skeletal Muscle: Could Your Beloved Coffee Do the Same?

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Image 1: If there is a connection between asthma and diabetes, it probably isn't related to the use of beta-2 agonists. What is one of the most dubious ailments among professional athletes? Asthma, right! Asthma is much better than the meat in Lenny Paul's bolognese of which he claimed that it must be responsible for the nandrolone the WADA officials found in his bloodstream 1997. I mean, even if you don't want to say that you used it yourself the truckload of clenbuterol (once used as a standard treatment for asthma) could still be for your poor asthmatic dog like the one professional cylcist, Frank Vandenbroucke, had squirreled away in his house just when the WADA ransacked his house. Now, less than a month after the publication of a study by Hamzeh Elayan, Milos Milic. Ping Sun, Sunir Gharaibeh and Michael G. Ziegler in the Journal of Cellular and Molecular Neurobiology ( Elayan. 2012 ), I suppose that the next top athlete who is going to be busted will probably cla...
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Adelfo Cerame - Road to The Wheelchair Nationals '12: Back From Thanksgiving and in Better Shape Than Ever!

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Image 1: Some people just know how to improve their physique even when pigging out on thanksgiving. Or can you see any collateral damage the turkey, the pie and the pie and the turkey from last week have done? Assuming that all of you have eventually overcome the physical and psychological consequences of your thanksgiving festivities, you should be about as ready as can be to kickstart the last three serious training weeks of the year. It alway amazes me how long some days (especially those without lectures and tons of paper work in the office) appear to be, when weeks and months fly by like nothing. I remember back in the day, when I first contacted Adelfo on behalf of the Suppversity Student Spotlight and we came up with the idea for this series, I was thinking to myself: "Damn, 2012? That is a going to be a hell long series of blogposts! Let's hope people will like it..." And now? Well, the title of the email I just received from Adelfo is " 2 months down! A...
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The Myostatin <> Clenbuterol Connection - More Muscle, Less Fat: Is an Orphan Nuclear Receptor the Missing Link?

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Image 1: Belgian Blue cattle are "naturally" myostatin negative. These beasts are 100% muscle 0% fat and though your usual clenbuterol fattened meatstock cannot compete, the heavily abused beta-2 agonist could infact work its muscle building, fat burning magic via very similar mechanisms. You have probably heard at least one of the dozens of reports on clenbuterol in pork, chicken, beef and lately sheep meat from China, haven't you? I mean, that kind of meat, innocent Tour de France competitors consume and end up with a positive doping test ;-) "Clenbuterol?", some of you may now ask themselves: "Isn't that the illegal fat burner bodybuilders use to get totally shredded in the last weeks of their contest prep?" Well, you are right, but " lean meat powder " ( CRJ. 2011 ), as our Chinese friends call it, has another, less known and hitherto not completely understood quality: Clenbuterol builds muscle! And while we did already know th...
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Higenamine: PES Introduces New "Fat Burner" to the Market. Potent Thermogenic or Dangerous Stimulant?

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Image 1: The reformulated PES Alpha T2 contains higenamine , alpha yohimbine and 3.3-diiodo-l-thyronine I just received an advertisement email containing some information about the reformulation of PES popular fatburner Alpha T2 (make sure to read " T2 a Fat Burner for Bulking? " for some details on the thyroid stimulating properties of 3.5-diiodo-l-tyronine the metabolically more active "brother" of the 3.3.-diiodo-l-tyronine in PES Alpha T2) mentioning a compound that is advertised as "an all new beta-agonist", that would have been found to be "more effective" than synephrine. While this claim did not impress me at all, I took the time and dug up some information about "higenamine"... The adrenergic effects of higenamine ( Hig. demethylcoclaurine ) have been well established since the 1980s ( Park. 1984 ). In fact, the cardioactive benzylisoquinoline alkaloid isolated from Aconiti tuber has long been used as a cardiotoni...
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