Posts

Showing posts with the label glucose intolerance

Popular topics

Show more

Even Low "Normal" Plasma Testosterone Levels Associated with 2.5x Higher Risk of Insulin Resistance

Written by | published on
"Your levels are in range!" Did you ever have your doctor say that to you? It appears as if next time you hear that sentence, you better ask him "Where 'in range' are my levels, exactly?" At least, the results of a recently published study by Menendez et al. ( Menendez. 2011 ) suggests that it might be worth digging somewhat deeper into this issue. Studying a cohort of 282 men (aged 36 to 85 years) who had "normal concentrations of total testosterone", the scientists found: Serum concentrations of testosterone and bioavailable testosterone were negatively correlated with age, body mass index, waist circumference, blood glucose, glycated hemoglobin levels and insulin. Serum concentrations of total testosterone, bioavailable testosterone and SHBG were lower in men with glucose intolerance or diabetes than in those with normal glucose tolerance. After multivariate analysis, age and total testosterone levels were independent predictors of the pr...
Read full article »

Dietary Oxidized Frying Oil Impairs Pancreatic Insulin Release. Vitamin E Helps!

Written by | published on
It certainly is no coincidence that a recent study on the detrimental effects of oxidized frying oil (OFA) was published in the British Journal of Nutrition . Afterall, it suggests that the British are at risk of dying out, if they just listened to their appetite and kept over-consuming "Fish and Chips". After feeding rats with either soy (HF) or oxidized frying oil (HO) over a period of 8 weeks the researchers found: [...] mice in the HO group showed glucose intolerance and hypoinsulinaemia, and their islets showed impaired glucose-stimulated insulin secretion (P,0·05; HO group v. LF and HF groups). Significantly higher oxidative stress and a lower mitochondrial membrane potential were observed in the islets in the HO group compared with the LF and HF groups. Immunoblots showed that the reduction in insulin levels in HO islets was associated with activation of the c-Jun NH2-terminal kinase and a reduction in levels of pancreatic and duodenal homeobox Furthermore, they ...
Read full article »

Mitochondrial Density in Muscle is Key Determinant of Metabolic Flexibility

Written by | published on
If you happened to have listened to Carl Lenore's interview with Mike T Nelson's on SuperHumanRadio , last week, you will be familiar with the concept of metabolic flexibility and how important it is for your body to be able to adapt quickly to varying energy demands and sources. A recent study by scientists from the Pittsburgh School of Medicine ( Chomentowski. 2010 ) had a similar background. Along with several markers of metabolic flexibility the group measured intermyofibrillar and subsarcolemmal (SS) mitochondrial content in a sample of forty sedentary adults with a wide spectrum of insulin sensitivity (insulin-sensitive lean subjects, insulin-resistant nondiabetic subjects, and subjects with type 2 diabetes mellitus). Intermyofibrillar mitochondrial content was lower in the insulin-resistant nondiabetic subjects and type 2 diabetes mellitus groups, significantly correlating with glucose disposal in both men (R = 0.72, P < 0.01) and women (R = 0.53, P < 0.01). In co...
Read full article »

Men More Prone to Lipid Induced Insulin Resistance than Women

Written by | published on
Regardless of the low-carb-craze of the last years, there is still plenty of scientific evidence that an overtly high fat intake (especially without restricting carbohydrate intake) puts you at risk of developing insulin resistance. What's new to the findings of Hoeg et al. (Hoeg. 2010) is that men are obviously more susceptible to lipid induced insulin resistance than women. At least this is, what the data obtained from the infusion of intralipid or saline for 7h to 16 young well matched healthy men and women suggest: Intralipid infusion reduced whole body glucose infusion rate 26% in women and 38% in men (p<0.05) and insulin stimulated leg glucose uptake was reduced significantly less in women (45%) than men (60%) after intralipid infusion. So obviously, if you are a male, you got to watch your blood lipids more carefully than women. As far as the reasons for this gender-bias are concerned the scientists are at a loss: This insulin resistance ...
Read full article »

Glucose Intolerance in Obese Rats Due to High Carb Not High Fat Diet

Written by | published on
While common wisdom tells us that a high carbohydrate + high fat diet will make us fat and sick. A new study by Fleur et al. ( Fleur. 2010 ) indicates that a free-choice high-fat high-sugar diet induces glucose intolerance in absence of obesity. Also, rats fed a high-fat (low carb) diet avoided the negative effects on insulin tolerance despite similar comparable body weight gains: Interestingly, the HF [=high fat] diet did not affect glucose metabolism , whereas the HFHS [=high fat, high sugar] diet resulted in hyperglycemia, hyperinsulinemia and in glucose intolerance because of a diminished insulin response. The researchers conclude... these results suggest that not only obesity or total caloric intake, but the diet content also is crucial for the glucose intolerance that we observed in rats on the HFHS diet. This is just another of a handful of studies published in the course of the last months which argue against the high-fat = diabetes theory, many people (including pra...
Read full article »
Disclaimer:The information provided on this website is for informational purposes only. It is by no means intended as professional medical advice. Do not use any of the agents or freely available dietary supplements mentioned on this website without further consultation with your medical practitioner.