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Beyond Vida's Book, Part 2/2: Androgen, Progesterone, Estrogen & Corticosteroid Receptor Activities of ALLmost All Anabolic Steroids - Metabolits, Progestins & More

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Image 1: Tetrahydrogestrinone aka THG, aka "The Clear" and the bone of contention in the "BALCO Scandal" could probably have been identified years before, if the WADA detectives already had the new  mammalian androgen responsive reporter gene assays at their disposal. As mentioned in part 1 of this post (cf. Beyond Vida's Book, Part 1/2 ), Houtman and the other scientists from BioDetection Systems B.V. and the Institute of Public Health and the Environment in the Netherlands, did not exactly want to provide juicers with data on which steroids may cause unexpected side-effects, when they conducted their study in 2008. The original idea was to demonstrate that their technology would be able to identify even those androgens, which have hitherto not been classified as illegal substances - so called "designer steroids", which would not turn up in the chemical–analytical approaches combining gas chromatography (GC) or liquid chromatography (LC) s...

Beyond Vida's Book, Part 1/2: Androgen, Progesterone, Estrogen & Corticosteroid Receptor Activities of ALLmost All Anabolic Steroids - WADA Prohibited Compounds.

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Image 1: Data on the interaction of androgens with the progesterone receptor is scarce, this study has it! This is only blogpost #499, yet at the same time, its a premiere! It's the first time that I am aware of that something you read at the SuppVersity has been covered by the "competition" before. Kudos to my dutch friends from ergogenics.org , who dug up a 2008 paper by Corine J. Houtman et al. ( Houtman. 2008 ) with extensive CALUX(R) bioassay data on the androgen, progesterone, estrogen and corticosteroid receptor response to allmost all popular steroids - it would probable be the "A", as in 4-androstenediol (the "good old 4-AD"), to "Z", if there actually was a common androgen with a "z" as its first character. Note! Due to the fact that the sheer amount of data from this study exceeds the time I can spend on analyzing and compiling it for you, today, this is going to be a two part series , with the second part on wh...

The (Re-)Discovery of 17{beta}-hydroxyestra-4,9,11-trien-3-one: Low Dose Trenbolone Safely Promotes Myotrophic Actions in Skeletal Muscle and Provides Partial Protection Against Bone Loss and Visceral Fat Accumulation

Sometimes it is interesting to see how agents that have been around all along reappear back on the medical scene, all of a sudden. A recent study conducted by a group of scientists from Florida ( Yarrow. 2011 ) that compared the effect of different doses of 17{beta}-hydroxyestra-4,9,11-trien-3-one aka Trenbolone on muscle hypertrophy and prostate health of testosterone seems to have the potential to trigger such a "revival": In both intact and orchiectomized animals, all TREN doses and supraphysiologic testosterone-enanthate augmented androgen-sensitive levator ani/bulbocavernosus muscle mass by 35-40% above Shams (p≤0.001), and produced a dose-dependent partial protection against orchiectomy-induced total and trabecular bone mineral density losses (<0.05) and visceral fat accumulation (<0.05). The lowest doses of TREN successfully maintained prostate mass and hemoglobin concent...
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