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Sesame Powered High Omega-6 Diet Boosts Endurance Performance in Rodents - High Omega-3 Diet Sucks: Intra-Muscular Lipid Ratios Determine Exercise Performance

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At least in rodents omega-6s appear to make abetter match with exercise than in human beings. I actually referenced this study several times in the past. It came up in a Facebook conversation I had with Roy Nelson who pointed me to a press release telling me that ( I quote ) "Certain Fat Could Help Humans Lose Weight". Interestingly, the "certain fat" in this particular study is (brace yourselves) linolic acid, better known as "omega-6" (obviously a misnomer, since omega-6 is actually referring to a whole class of fatty acids). In view of the fact that the corresponding study in which Rogowski et al. observed a significant correlation between the omega-6 fatty acid content in the muscle and mitochondrial uncoupling and fat oxidation. The problem with the study is however that it was conducted not just with mice, but with genetically modified mice. The results of the said study by Rogoswki, Patin et al. may thus form the basis for further investiga...
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Devil in the Feeding Trough: PGE-Response to "Bad" Red Meat from Grass-Fed Cattle Could Prevent not Cause Cancer, Stroke and a Whole Host of Autoimmune Diseases.

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Image 1: You do not need to hunt your red meat like a paleolithic human being, just make sure it comes from grass-fed animals and you will have a "health food" that modulate the your prostaglandin response to inflammatory assaults and thusly reduce your risk of cancer, stroke and autoimmune disesases in a way no fat-free chicken breast will ever do. I have had this in the news before, in the context of the purported health benefits of CLA, with respect to the modulation of the n3/n6 ratio in your diet and in various other context, you heard me saying, or, I should say, read me writing that rather than popping tons of fish oil caps, you should rather focus on decreasing your overall omega-6 intake by making healthy food choices at the supermarket. In this regard, choosing grass-fed over commercially raised beef (and other meat) products could turn out to be one of the most far-reaching choices you can make. While that alone will help you to concomitantly reduce the n-6 ove...
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N3-PUFA Beneficial Only When Combined With Antioxidants

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All of you who have been following this blog, lately, will have noticed that I tend to be skeptic whether fish oil and other PUFA supplements are recommendable without certain reservations. A recent study by Filaire et al. ( Filaire. 2011 ) seems to support the view that poly-unsaturated fatty acids increase the potential for oxidative damage and should thus be combined with appropriate amounts of antioxidants to "compensate" this effect. Over a period of 6 weeks the researchers supplemented a group of 36 judoists with either 600 mg EPA and 400 mg DHA per day or the same amount of long chain polyunsaturated fatty [LCPUFA] acids plus 30 mg vitamin E, 60 mg vitamin C and 6 mg β-carotene and measured resting and exercise-induced lipid peroxidation in their subjects. Here are the results: At T (1) [before supplementation], there were no significant differences among treatment groups with respect to lipid peroxidation, lag phase, and levels of α-tocopherol o...
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Don't Blame Your Parents for Getting Fat: N-3 Fatty Acids May Save You!

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Figure 1: Chemical Structure of Alpha-Linolic Acid ( HMDB v2.5 ) It has been assumed that bad dietary habits of mothers-to-be increase the risk of their offspring to become obese. As Oosting et al. ( Oosting. 2010 ) report the consumption of a diet high in n-3 Long-chain polyunsaturated fatty acids (n-3 LCP) may well prevent you from this fate, even if your mother was a fast food maniac: A n-3 LCP-rich diet during postnatal life not only reduced fat accumulation by approximately 30% during the WSD [western diet = high fat, high carb] challenge from PN42 to 98 (p<0.001), but also led to a healthier plasma lipid profile, healthier plasma glucose homeostasis and less hypertrophic adipocytes compared to CTRL. This study shows that postnatal nutrition has programming effects on adult body composition and metabolic homeostasis. Additionally, it emphasizes that moderate alterations in fat quality during early postnatal life considerably affect adult metabolic health. Well, t...
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