Fat and Impotent Due to Tributyltin? Not Adipogenetic or Estrogenic, But Adipogenic and Estrogenic. Organotin TBT Dose-Dependently Increases Fat Deposition and Estrogen Receptor Activity.
Image 1: Chemical structure of tributyltin; the organotin is a common ingredient in pesticides, anti-fungals and marine paints Although large parts of the industry won't concede to it, many of the invisible pollutants of our "post-industrial" age are just as, or even more dangerous than the nasty air and water pollutants of the Industrial Revolution. One of these invisible killers is the organotin, tributyltin (TBT) . It has been long established that TBT exposure during fetal life promotes adipogenesis and predispositions to a multitude of health problems in later life ( Grün and Blumberg, 2006 ) . Other than in other environmental toxins, such as Bisphenol A, it has been established only very recently that TBT may act as an estrogen receptor agonist, as well - in fact, in previous (low-dose) studies ( Lissimachou. 2006 ; Mortensen. 2007 ; Zhang. 2009 ) the exact opposite appeared to be the case. ...