Citrus Aurantium / Synephrine for Weight Loss: What Science Tells Us
It was praised as the ultimate safe replacement for ephedrine and has been present in numerous fat burner for years. Lately, synephrine is disappearing from the next-generation fat burners and there appears to be some reason for that. A 2004 review by Fugh-Berman & Meyers (2004) had already established: There is little evidence that products containing C. aurantium are an effective aid to weight loss . Synephrine has lipolytic effects in human fat cells only at high doses, and octopamine does not have lipolytic effects in human adipocytes. Just taking more synephrine to achieve the required levels, on the other hand, is dangerous. As a study by Arbo et al. (2009) indicates, Citrus aurantium (400/2000mg/kg) consumption leads to oxidative damage in mice: There was an increase in reduced glutathione (GSH) concentration in groups treated with C. aurantium 4000 mg/kg and p-synephrine 30 and 300 mg/kg. In glutathione peroxidase (GPx), there were an inhibition of the activity in C...
