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100-200ml Red Wine Per Day Improve HDL and the LDL/HDL Ratio With & Without Mediterranean Diet & Exercise

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Good for him, good for her, good for everyone? Is it really possible that red wine can help even those who don't want to the necessary lifestyle changes? You all know about the limitations of epidemiological studies and the fallacy of the over-generalization of associations between health parameters and red wine consumption in the mainstream media. For me this *bs* is so annoying that I usually don't even take a look at "red wine studies". Luckily, a recent paper by Dirk W. Dorste and his colleagues did still catch my attention: It's about to be published in the December issue of Nutrition Journal and is not based on epidemiological data. The Luxembourgian scientists gathered their data in the course of a randomized unblinded 2-year trial that involved 108 patients with carotid atherosclerosis and >30% reduced blood flow (65% of the patients were on statin therapy). 122 patients, 4 intervention groups, red wine and/or lifestyle changes While half of ...
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Heart Protective Effect of Red Wine not Exclusively Due to Resveratrol. Melatonin Potentially the Major Player!

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Resveratrol, the red wine polephynol still is in everyone's mouth (literally, as well as metaphorically), yet a recent ( Lamont. 2011 ) study published in the Journal of Pineal Research indicates that another hitherto overlooked constituent of the fermented grape juice factors into its protective value: Melatonin. Lamont et al. found that, at the doses which can be found in red wine, naturally , individually, as well as in combination resveratrol and/or melatonin ... ... significantly reduced infarct size compared with control hearts in wild-type mouse hearts (25 ± 3% and 25 ± 3% respectively versus control 69 ± 3%, P  < 0.001) [...] Furthermore, perfusion with either melatonin or resveratrol increased STAT3 phosphorylation prior to ischemia by 79% and 50%, respectively ( P  < 0.001 versus control). Both, melatonin, as well as resveratrol, appear to work via the "survivor activating factor enhancement" [SAFE]. What I consi...
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Resveratrol Fails to Ameliorate inflammatory response and Delayed Onset Muscle Soreness After a Marathon

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Resveratrol , an antioxidant polyphenol from the skin of red grapes, has now been around for quite a while and as it was in the case of almost every other antioxidant which was hailed as a powerful panaceum (e.g. vitamin E ) it slowly transpires that the real life value of resveratrol may well fall short of the expectations its potency in (mostly) in vitro studies rose among scientists and laymen alike. For some of you it may yet still come as a surprise that the results of a double placebo-controlled randomised trial conducted at the London Marathon 2010 ( Laupheimer. 2011 ) fall short of the expectations the colorful advertisements and cited abstracts from in vitro studies may raise in many half-informed customers: There was no significant difference between the two groups in terms of changes occurring between pre and post-tests for WBC [white blood cell count], CRP [C reactive protein] or VAS [a measure of muscle soreness] (p=0.857, 0.629 and...
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