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Role of Magnesium in Blood Sugar Management

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In a recent study ( Guerrero-Romero. 2011 ) a group of scientists from the Research Group on Diabetes and Chronic Illnesses from Durango, Mexico, investigated the effect of oral supplementation with magnesium chloride (MgCl(2) ) on "the ability of beta-cells to compensate for variations in insulin sensitivity in [52; placebo + treatment] non-diabetic individual". Obviously, we hear it over and over that 'magnesium is the fourth most abundant mineral in the human body', it is vital, etc., etc. - studies showing real life benefits from oral supplementation are however relatively scarce. Unfortunately, there is one caveat with this study, as well. Guerrero-Romero et al. deliberately selected only those subjects with "significant [magnesium levels ≤0·70 mM/L] hypomagnesaemia, i.e. low magnesium levels. There were no serious adverse events or side effects because of MgCl(2) or placebo. At the beginning of the study, the AUC of the HMbCF was similar in both group...
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Oral ATP Supplementation Proves Completely Ineffective Even at Very High Doses

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I think most supplement companies have hitherto given up on convincing you of the use of oral ATP supplements. About 2 month ago, I did however notice a new "high dosed" product (I cannot remember the figures out of my head, but the daily dose was far below 1.000mg) was released to be bought by the in-educated public ;-) Just to discourage you from wasting your money on any such products, here is a very recent study ( Coolen. 2010 ) on the futility of attempting to rise ATP levels via oral supplementation: Thirty-two healthy subjects were randomised to receive 0, 250, 1250 or 5000 mg ATP per d for 28 d by means of enteric-coated pellets . In addition, on days 0 and 28, all thirty-two subjects received 5000 mg ATP to determine whether prolonged administration would induce adaptations in the bioavailability of ATP. ATP supplementation for 4 weeks did not lead to changes in blood or plasma ATP concentrations. Of all ATP metabolites, only plasma uric acid levels ...
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Potratz on SHR: Grape Fruit Oil for Enhanced Oral Steroid Resorption

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Just for those of you who are not yet addicted to the Super Human Channel , i.e. Carl Lenore 's radio program on exercise, nutrition and longevity: Wednesday, 15 December 2010, Carl had Eric Potratz from Primordial Performance on the show and talked to him about what could be the future of oral drug/steroid delivery. Although the show certainly smacks of a product pimpjob, the general information Potratz provides is scientifically correct. Audio 1: Super Human Radio - 631 - Oral Hormone Delivery And Bioavailability Potratz main argument that grape fruit blocks the intestinal esterase, i.e. the removing of the ester attached to a steroid to render it absorbable via the lymphatic system, has been confirmed in several studies. More recently, Li et. al. ( Li. 2009 ) reported: [..] oral coadministration of GFJ [Grape Fruit Juice] or an esterase inhibitor, bis-( p -nitrophenylphosphate), with the prodrugs led to respective increases in plasma area under the ...
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Are Micronized DHEA and Similar "More Bioavailable" Preparations Worth It?

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The scientifically mostly unbacked attention the micronized preparations of DHEA and Pregnenole receive all over the web raised my interest in whether the claims of higher bioavailability are warrantable. It turned out to be difficult to find conclusive answers (apart from the webpages of the producers and retailers, of course ;-), but I came up with the results of a 1996 study on the delivery of micronized preparations of dehydroepiandrosterone (DHEA) to premenopausal women [ Casson. 1996 ]. The researchers conclude: Micronization increased the area-under-the-curve ratios for dehydroepiandrosterone sulfate/dehydroepiandrosterone and dehydroepiandrosterone sulfate/testosterone. Or in other words: A significantly lower amount of DHEA is converted to androgens , upon administration as a micronized preparation (cf. Fig.3 from Casson. 1996 , to the left) . The inclusion of a lipid matrix, like some companies have it, may further potentate this effect. However, scientifical validation ...
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