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Maintain & Increase Your Insulin Sensitivity - Wrap-Up: Overview + 3 Stacks. Plus: AMPK & PPAR-γ Revisited

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It's not about exercise or nutrition, it's about both of them. And as long as it is not about the former it should not be about supplements either. It's Sunday and finally time for the wrap up of the "Maintain & Increase Your Insulin Sensitivity" Series ( read all previous installments ). It took me quite some time to get through all the compounds on my and your list and the outcome is far from being a "complete" list of all the agents that can have beneficial effects on your insulin sensitivity. Still, if there is at least one agent, one fact or one take home message for each of the 6 previous articles of which you would say: "Ok, I guess that was worth wasting some of my valuable time on", I would be happy. For myself it was by the way yet another occasion to learn more  about many of the agents, I reviewed in this series . And if you listened to the SuppVersity Science Round-Up on Thursday , you will probably remember that I said...
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Fighting to Stay Lean? These 20+ Anti-Obesity Agents Have the Potential to Inhibit Fat Gain Right at the Cellular Level

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No, none of the 20 agents in the list below is going to do the work for you, but they could help you "conserve" the results, keep you lean on a bulk and/or avoid the hazardous Yoyo effect when you go off a die. It's actually normal that the introduction is the last part of an article I write. What's special about today's SuppVersity article is thus not that I write the introduction at the end, but that I did not really know what I would be writing here, when I set out to compile the unsorted (but not chaotic) list of potential anti-obesity agents below. All of them act by pathway(s) you as a SuppVersity reader will have read about before, most prominently AMPK , and the peroxisome proliferator receptors (PPARs), of which the blockade of the obesogenic PPAR-gamma pathway, which is the main working principle of CLA turned out to be the go-to explanation for the ability of these agents to block both the differentiation of adipocytes and the storage of tr...
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20 Weeks of Gluttony Without Gaining a Single Gram of Visceral Fat? A Water Extract From Hops Made It Possible

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Hops: More than an ingredient of the majority of OTC sleeping pills (photo LuckyStarr) Hops beer made from the female flowers of Humulus lupulus was the (safer) alternative to untreated water in medieval Europe. Hops are the female flowers (also called seed cones or strobiles) of a hop species and are currently still used as a flavoring and stability agent in beer. Aside from that, the vigorous, climbing, herbaceous perennial has a longstanding history of medical uses and is probably best known for its sedative effects. That a hot water extract from hop could make an excellent addition to an anti-obesity and even fat loss regimen is yet news and - in view of its efficacy - even SuppVersity news ;-) Eat like a pig, look like a goddess with hops! Actually the subheading is pretty unfair, after all pigs don't eat much different from us, they are opportunistic omnivores... but this is no biology lesson, so let's get back to the topic at hand. There was a time, when I thou...
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Vitamin D, PPAR-γ & the Growth of Healthy Body Fat Stores; Betaine & Fat Inflammation; Free HMB & Muscle Protection; DHA Induced Forgetfulness & Statistical Shenanigan

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"Is it already 2013? Must be the DHA, I totally forgot." The SuppVersity or rather my personal figure of the week was and still is 2013. I actually managed to write 2012 instead of 2013 with every damn study in today's installment of On Short Notice that has been published online in the last couple of days. I wonder how long it will take me to get used to it  - that's like a "new year's date jetlag" ;-) Now, usually the figure of the week has at least something to do with the topics I am writing about, so I decided to add not another figure, but rather some stats, namely the TOP3 SuppVersity posts (by visitors) from the year that still appears to be programed into my system - 2012: "Particle Size & LCAT Analysis Shows: Three Whole Eggs per Day Improve Lipid Profile in Men & Women W/ MetSyn" ( read more ) "22g Baking Soda 60min Before a Old-School 4 x 12RM Leg Workout Allow for a 22 Rep Volume Increase on Hypertrophy ...
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Yohimbine & Berberine Protect From Death Due to LPS Intoxication; BCAAs Inhibit Serotonin Metabolism & Cause Anxiety, Tryptophan but not SSRIs Help; Sweet Tea Leaves Are PPAR-G Antagonists & Battle High Lipid + Leptin Levels

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Skip the fireworks invest the money in some quality ingredients for a fondue or whatever you like and invest the (often non-negligible) rest of the money in a gym membership for the next year. Actually my figure of the week is 115,000,000 EUR (~152,000,000 US Dollar), which is the sum my fellow country men and women are about to waste on pyrotechnics this year. And a scientifically unconfirmed addition based on my personal observation: 90% of the worst offenders as far as spending money for fireworks goes are at least overweight. Would be interesting to see, if the use of pyrotechnics on New Years Eve is directly associated with fat mass... I mean, it could be that they spent so much money on their fireworks that they feel they can only afford the junkfood of which everybody and his/her mama still tend to believe that it would be cheaper than buying fresh products and preparing your own food from those. Ah, I am ranting. That's usually Carl Lanore 's task, so I will bet...
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