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Do the Anti-Alzheimer's Effects of Grape Seed Extract (GSE) Start in the Gut? Your Gut Bugs Could Save Your Brain

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The gut may be the missing piece to the Alzheimer's puzzle. It is well-established that an phenolic extract from the seeds of grapes (GSPE) can have significant anti-Alzheimer's and general neuroptective and anti-dementia effects (Sarkaki. 2007; Balu. 2005; Wang. 2009). In their latest study, scientists from the University of Queensland  did now, for the first time, investigate the role your intestinal microbiota may play in the metabolism and production of orally ingested and newly formed polyphenolic compounds that will then mediate the attenuation of Alzheimer’s disease β-amyloid oligomerization. If you are concerned about brain health, keep an eye on your  circadian rhythm Sunlight, Bluelight, Backlight and Your Clock Sunlight a La Carte: "Hack" Your Rhythm Breaking the Fast to Synchronize the Clock Fasting (Re-)Sets the Peripheral Clock Vitamin A & Caffeine Set the Clock Pre-Workout Supps Could Ruin Your Sleep While it is well-kn...
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1.3g of Grape-Seed Extract Could Protect You From Oxidative Damage, Viral Infections, Obesity and Insulin Resistance, Reduce Your Heart Rate and Blood Pressure and Increase Your Nitric Oxide Production by >25%

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Image 1: Bought in bulk, grape-seed extract is actually reasonably cheap... and it does not even taste as awful as some other herb / seed extracts ;-) After initially being hailed as the yet another anti-oxidant panaceum, grape-seed extract (GSE) has been displaced by newer, fancier "superfoods" from the headlines of the major health and wellness newscasters. Therefore, even you, as a highly self-educated student of the SuppVersity could have missed out on a handful of recently released studies which reported antiviral effects of GSE ( Su. 2011 ) and confirmed its ameliorative effect on diet-induced obesity ( Ohyama. 2011 ) and (high) fructose-induced insulin resistance ( Meeprom. 2011 ). Moreover, a meta-analysis of nine controlled with more than 300 human subjects and daily doses ranging from 250mg to 2,000mg of GSE, which was published in the Journal of the American Dietetic Association ( Feringa. 2011 ), found that ... [b]ased on the currently available literature...
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Mitochondrial Proanthocyanidin-Tuning: Fruit & Seed Extracts from Grapes Cheer Up Tired Mitochondria.

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Image 1: Grapes - mitochondrial super food. While I am still not sold on the idea that the unfortunate and unhealthy fate of being a fat slob is in your genes , it is a commonly accepted scientific fact that lifestyle factors (and thus epigenetics) contribute to obesity related mitochondrial dysfunctions. Defective cellular powerplants, on the other hand, make it increasingly difficult to lose weight and may be one of the major causes of the weight(re-)gain the majority of dieters experience after ardeous weeks of (un-)successful calories-in-vs-calories-out dieting. The results of two very studies published in the latest issue Journal of the American Chemical Society ( Kang. 2011 ) and the Journal of Food and Chemical Toxicology ( Arola. 2011 ) indicate that both the proanthocyanidins from grapeseeds, as well as the mixture of bioactive substances from whole red grapes may ameliorate the impairment in oxidative capacity and de...
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