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Amino Acids for Super Humans, Part IV - Purported Ergogenics (2/3): L-Carnitine, ALCAR, LCLT, GPLC & Co.

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Image 1: Even bought in bulk, the carnitines are not exactly cheap, so you better read on to gather whether ALCAR, L-CAR, P-LCAR, L-CLT & Co are worth spending money on. Despite the fact that even my grandmother has heard of the miraculous energizing and fat-burning abilities of carnitine, most people - and even those who are buying those carnitine-enriched functional, or should I say disfunctional foods are not even aware that L-3-hydroxy-4-N,N,N-trimethylaminobutyric acid (l-carnitine) is a naturally occurring amino acid, all mammals (humans included) can synthesize from l-lysine or l-methionine in their livers and kidneys. Necessary co-factors for carnitine synthesis are ascorbic acid (vitamin C),  pyridoxine (vitamin B6),  niacin (vitamin B3) and  S-Adenosyl methionine (SAMe) Interestingly, supplementation of the EAA substrates and co-factors failed to raise carnitine synthesis and or serum levels in respective studies. Gamma-butyrobetaine, ...

Chronic L-Carnitine L-Tartrate Supplementation Increases Exercise Induced Carbohydrate Oxidation in Men

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Figure 1: Molecular structure of L-Carnitine ( HMBD v2.5 ) Carnitine supplementation is commonly advertised as a means to shift substrate metabolism from carbohydrate to fat. A new study by Abramowicz and  Galloway indicates that - at least for L-Carnitine L-Tartrate (LCLT) - the opposite is the case. Carbohydrate oxidation was significantly increased in following chronic supplementation 93.8 g/hr vs. placebo 78. This shift in substrate metabolism was not observed in the female subjects, though. From a more general perspective the result that "No effects on fat oxidation or hematological responses were noted in either gender group." may well be of greater importance to the average gym-rat tempted to invest his hard-earned money into colorfully marketed carnitine products .
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