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MTHFR Mutations, Cardiovascular Disease, and Riboflavin (B2): Scientists Zone in on a Neglected Ménage à Trois

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You can test your MTHFR gene either directly  or by plugging your raw data from 23andme, or another provider into evaluation tools such as Genetic Genie . If you have no idea what #MTHFR means, here's the Reader's Digest version: MTHFR is an enzyme that is affected by a mutation in the MTHFR gene. The latter encodes the enzyme methylene-tetrahydrofolate reductase a ka MTHFR effectively unless there's a single-nucleotide polymorphism (SNP) affecting the 677th base pair of the MTHFR gene... not helping? Well, let's just say if you have a certain variation of this gene, you're having a hard time processing B-vitamins; and it's not totally unlikely that you're affected : According to  Marini et al. 2008 , this mutation affects 29% of the global population. Previous studies, however, report much lower estimates for prevalence of the MTHFR 677TT genotype, i.e. 10% worldwide, with values ranging from 4 to 18% in the United States, over 20% in Northern China to ...
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Carbs Before Workout Won't Lock Your Ab Fat in its Stores | Plus: Wired for Laziness, Standing for Your Health and 'Cardio' Reversibly Promotes Microbial Diversity in Guts

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Spiking insulin w/ high GI carbs before a workout doesn't blunt the release of fat from the stores covering your abs. Whenever I hit on journals like the latest issue of Medicine in Sports Science , a publication by the American College of Sports Medicine . I contemplate using them as a resource for an installment of the short news - albeit only if more than one of the studies in said journals are actually worth talking about. For the November issue of Medicine in Sports Science , this was the case for four studies. First and foremost, probably Baur's experimental counterevidence to the hypothesis that the carbohydrate-induced surge in insulin would 'seal' your subcutaneous body fat stores. It may not be necessary to attack your ab-fat, but fasting does have a handful of benefits: Monthly 5-Day Fast Works "Lean Gains" Fast Works Habits Determine Effects of Fasting Protein Modified Fast 4 Health IF + Resistance Training = WIN ADF Bea...
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Training in Line W/ Your Genetic Potential Can Boost Your Performance Gains More Than 600%, DNAFit™ Studies Say

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While the study at hand appears to confirm that the DNAFit test can tell you if you're an endurance or strength athlete, it won't help you achieve goals you were not "made for" - it eventually you may thus have to give up your dream of being the fastest, strongest or most chiseled guy / gal on the track, field or in gym. You probably know that: There's that guy at the gym who has been training only half as long as you and still made twice the gains, ... must be juicing that idiot, right? Well, even if we assume that you're not one of the >50% of trainees who overtrain (and undereat) that's by no means the most likely explanation for the astonishing discrepancies. A recent study that was conducted by a consortium of European researchers is now the first to impressively demonstrate that "matching the individual’s genotype with the appropriate training modality leads to more effective resistance training" (Jones. 2016) What the scientists s...
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Calculated Energy Requirements ±15% & More Off of True Resting Energy Expenditure | Genotyping May Help Maintain Muscle While Dieting -- ISSN'15 Research Review Issue #5

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In view of the inaccuracy of the standard equations that are used to calculate our energy requirements we are approaching the age of the "misquantified self". If I had to find a common theme in the studies discussed in this installment of the ISSN'15 Research Overview , I guess it would be "get lean and stay lean" . If you asked for a common bottom line, it would be: It's complicated . Complicated , because even though our genes appear to have a determining rule in what's the best diet for us, the "calories in vs. calories out" equation is eventually going to determine whether you are losing or gaining weight. That's problematic, not just because many of us have lost their inborn ability to match their energy intake to their individual requirements. It's also problematic in view of the increasing number of people who rely on the numbers of apps and fitness-trackers which are just as unreliable as the standard equations that were f...
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Short Bursts of High Intensity Circuit + Plyometric Training Keeps Blood Sugar "In the Zone" - No Matter If Your Parents Were Obese Diabetics, Or Lean Athletes!

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Circuit Train Your Way Out of the Type II Diabetes Trap - High Intensity Resistance Training + Plyometrics Work Regardless of "Bad Genes" | It's your Lifestyle not your destiny that determines whether you'll become and insulin resistant lifestyle diabetic or not. While many people still believe that "cardio" training was the only way to keep your blood sugar levels under control, anyone who knows something about exercise physiology will argue that a highly anaerobic exercise regimen, just like high intensity resistance training, for example, should be a way more powerful blood glucose normalizer than a 20-40 minute jog. I guess this was what Ryan D. Russell, Arnold G. Nelson, and Robert R. Kraemer must have had on their minds, as well, when they planned their most recent experiment. An experiment that was designed to (1) determine the clinical benefits of "high intensity-resistance-focused" exercise training (HIRFT) in  healthy young people ...
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