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How Diabetics Can Benefit Tremendously From Vitamin C and What Else the 1st Studies from 2019 Teach Us About Ascorbic Acid, Cancer, Antibiotic Side Effects & 'ur Gainz

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Vitamin C ain't yellow, but it's not as black-and-white as it is portrayed on social media, these days. A couple of years ago, the #1 discussions about vitamin C one could have would usually address the following questions: "Does vitamin C prevent/treat the common cold?" and... (I still get this question, by the way) "Is ascorbic acid/manmade vitamin C bad for your health?" Don't worry, neither of these questions is going to be re-addressed in this short C-special (for the latter question, I suggest you re-read my article about 'natural' vs. 'synthetic' vitamins, here . Learn more about hormesis and how antioxidants can also impair your gains Anti-histamines, exercise and your metabolic health Even Ice-Baths Impair the Adapt. Process Vit C+E Impair Muscle Gains in Older Men C+E Useless or Detrimental for Healthy People Will ALA, Berberine & Co Ruin 'Ur Gainz? Antiox. & Health Benefits Don't Corre...
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NAC Lowers DOMS, Initially, but on Day 5-6 it Makes Things Worse | Plus: Putative Performance Benefit is Negligible

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In the long run, choking the exercise-induced fire too much is going to negate all the cherishable benefits of working out. As a SuppVersity  reader, you know what hormesis is and are aware that the proinflammatory assault of exercise, is an essential stimulant to musculoskeletal adaptation - a number of human and dozens of animal experiments show: if you quell the production of pro-inflammatory reactive oxygen species with high doses of vitamin C and E the growth and health response to exercise will be impaired. And vitamin C + E are not the only radical scavengers with this side effect. In 2013, I wrote about a study  that clearly demonstrated how N-acetyl-l-cysteine aka NAC "Reduces Inflammation, Muscle Injury & Cytokine Expression, but Impairs Anabolic Signaling, Satellite Cell Activity and Recovery" ( re-read it ) - keep that in mind before getting overly excited. Read about exercise- and nutrition-related studies in the SuppVersity Classic Articles ...
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Research Update: Do NSAIDs Augment or Impair Exercise Induced Hypertrophy & Strength Gains in Young and Old?

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Are you young and healthy? Then, high-dose NSAIDs may ruin your quad-gainz. If you browse the SuppVersity   Archive , you will find that NSAIDs, i.e. Non-Steroid(=not based on cortisone)-Anti-inflammatory-Drugs like aspirin, celecoxib, diclofenac, ibuprofen, or indomethacin, are not as bad as the bros in the locker-room may have told you. In fact, a relatively recent study by Mackey et al. (2016) observed  beneficial effects on muscle repair in young men . And an even more positive image of NSAIDs emerges if you read Trappe et al.'s 2016 study in which they observed significant increases in muscle gains in older trainees. Read about exercise- and nutrition-related studies in the SuppVersity Short News Alcohol, Microbes & International Chest Day Will Cooking Ruin the N3s in Your Fish? Learn What's Really Driving Your Gains HbA1c, Bone Health, BFR & More | Jan'17 TeaCrine®, ALA, Tribulus, Cordy-ceps, Sesamin... The Latest Fiber & ...
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Low Dose Silymarin (Milk Thistle) Boosts Reduction in Body Fat % W/ Both, Strength (-9%) & Endurance Training (-11%)

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The "classic" user of silymarin supplements is either fat, sick and suffering from NAFLD, or big, buffed and taking oral steroids. Athletic women like the ones in the photos above, on the other hand, have not yet  been very likely to buy and use silymarin supplements... well, unless they were (ab-)using oral, hepatoxic steroids, as well, obviously. When bros talk about Silymarin, the active ingredient in milk thistle, they usually do that in the context of "cycle support", i.e. the use of supplements to buffer the negative effects of (oral pro-)hormones on organ- and, specifically, liver-health. A recent study from the  Ahvaz Jundishapur University of Medical Sciences  in Iran, however, the "bro-talk" may change that, though. In the study, which was meant to test, whether silymarin a scientifically proven (Dixit. 2007; Saller. 2009; Surai. 2015) "powerful antioxidant" (Shirali. 2016), will also affect athletic performance, N = 45 (unfortuna...
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Antihistamines Block Gene Response to Exercise + Impair its Insulin-Sensitizing, Energizing & Hypotensive Effects

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Is all the exercise you do for nothing if you have to take antihistamines? Unlikely, but what appears to be certain is that they have indeed negative effects on the exercise-induced adaptation process that triggers not just increases in insulin sensitivity, but also improvements in blood pressure and mental energy. "An antihistamine is a type of pharmaceutical drug that opposes the activity of histamine receptors in the body," that's what Wikipedia knows about antihistamines. This, and the fact that there are H1-antihistamines and H2-antihistamines, that they target the histamine H1/2-receptors and that they are used to treat "problems" from allergic reactions in the nose (e.g., itching, runny nose, and sneezing) to insomnia... quite the range ;) What Wikipedia does not know, however, is that histamine is "important substance contributing to the normal day-to-day response to exercise in humans" (Romero. 2016a) and that blocking it will also blo...
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