Thursday, July 22, 2010

Cirsimarin: An Almost Completely Overlooked Lipolytic Agent

It is interesting that, with the exception of USP Labs, who happen to have a talent to find "unorthodox" ingredients for their products, no supplement company has yet sourced an extract from Microtea debilis. After all, a similar extract ("similar" to the one used in USP Lab's Recreate) was found to
exert strong lipolytic properties being 20 times more potent than caffeine
in a 2005 study by Girotti (cf. Girotti, 2005 Fig.1, below)
Although the mechanism of action has not yet been fully investigated, a previous study by Hasrat found an antagonistic interaction with adenosine receptors similar to that of caffeine (Hasrat. 1997). The exact effect of Cirsimarin differs however from that of caffeine and the less pronounced effects Gingko biloba, so that the researchers conclude:
"This suggests that [...] the lipolytic activity of cirsimarin is related to another mechanism. [...] Studies to identify the precise mechanism of action of cirsimarin on lipolysis should involve phosphodiesterase inhibition." (Girotti, 2005)
This means that the mechanism of action (MOA) of cirsimarin would eventually be that of a phosphodiesterase inhibitor, which prevents the deactivation of cAMP- and cGMP-activity and thus increases energy uptake and -use of the cells.

Before you run to the supplement-shop of your choice and invest your peanuts into a bottle of Recreate, you should remember that lipolysis does not equal fat loss! If you do not force your body to consume the triglycerides it is breaking down inside the cells (preferably your muscles while your working out), its unlikely you will see results. So keep your diet in check, work out hard and maybe supplement with some lipolytic agent, such as Cirsimarin, the existence of which will hopefully be discovered by other supplement companies in the near future.