|Back in the day, when the original Oxy-ELITE Pro was pulled from the market, people paid crazy amounts of money for the bottles that were left on Ebay - a big mistake! Not because it would fry your liver, but rather because it's 'stim' effects will - just as those of other DMAA products - turn against you, w/ chronic use.|
It's those people I want to advice: Even if you ascribe the liver damage as the result of stupid overdosing and acknowledge that other products appear to be far worse (García-Cortés. 2016 | FFT), don't waste your money on DMAA products, in general, and the original OxyElitePro (OEP), in particular. And here's why...
The "why"s are based on a recent study from the Department of Physiological Sciences at the University of Espírito Santo (Zovico. 2016) in Brazil. The study was originally conducted to "to evaluate acute and chronic OEP affects, at controlled doses in Wistar rats, on physical performance, metabolic parameters, liver injury markers and oxidative stress markers and mitochondrial biogenesis in skeletal muscle. A study of which you'd guess that it would long have been done in view of the fact that serious adverse effects have been reported after OEP consumption, all over the web.
|Figure 1: Photo of the original OxyELITE Pro bottle and supplement facts label (Google Image Search).|
- The Good: OEP simply works -- If you are one of the previously referred to users of the product, you will probably remember your first training "on OEP". How would you describe it? Probably similar to the rodents in Zovico's study, who easily ran 2.6x and 2.8-fold further with the medium, respectively, the high dose of OPE in their blood.
"[n]o effect was found in other analyses such as spontaneous physical activity, body weight, food and water intake, hepatic toxicity, cardiac oxidative stress and mitochondrial NA amount" (Zovico. 2016),... you will now probably (and rightly so) ask yourselves: "So, what's 'the Bad', then, if it's not liver or heart damage as they both have been reported allegedly as a consequence of the (ab-)use of both, OxyElitePro and DMAA based products, in general?"
- The Bad: No liver damage, but potentially impaired adaptation to training -- Ok, part of the previously discussed "good news" was that there was no measurable - or, I should say - no sign. changes in AST, ALT and GGT (liver health) and even small beneficial effects on TBARs, i.e. lipid oxidation in the group of rodents that received the medium dose of the supplement (see MDA levels in Figure 3).
Figure 3: Oxidative stress measured in MDA per mg or protein (left) and mRNA activity PGC-1A, a primary
marker of exercise-induced mitochondrial biogenesis (Zovico. 2016).
Since this occurs only with the high dose of the supplement, i.e. 25.8 mg/kg or ~1.5-2 caps for a human being. This effect is bad, but not downright ugly - speaking of which...
- The Ugly: OEP simply stops to work -- If you belong to the group of former OEP users I've previously alluded to and/or have used any other DMAA product more than once or twice, you will probably remember "the Ugly", anyway: After only a few workouts "on OEP" (or any other DMAA) products, the effects began to vanish.
Figure 3: Relative endurance performance with acute and chronic (4 wks) supplementation (Zovico. 2016); all data expressed relative to the values of the control group on day 1 (cf. Figure 2).
Whether that's related to and/or a consequence of the previously discussed reduction in PGC-alpha expression in the chronically supplemented rodents would have to be investigated in future, studies - it does not seem unlikely, to say the least.
- García-Cortés, Miren, et al. "Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics." International journal of molecular sciences 17.4 (2016): 537.
- Zovico, et al. "Effects of controlled doses of Oxyelite Pro on physical performance in rats." Nutrition & Metabolism201613:90 | DOI: 10.1186/s12986-016-0152-4 [ahead of print].