Testosterone Gel Augments Increases in Lean Mass Gains (+3.9kg in 6 Months) in Older Intensely Training Men, but Testim Blocks Decrease in Marker of Heart Disease Risk
|Building muscle becomes increasingly harder, the older you get. While there's no evidence that any of the overpriced natty T-boosters can solve this problem, Testim(R) can. That's at least what a recent Danish study shows.|
In view of the fact that it took transdermal testosterone gels and a 100% increase in bioavailable testosterone (most T-boosters boast of boosting total testosterone by 20-40%) in a recent study from the Odense University Hospital and the University of Southern Denmark (Glintborg. 2015) to trigger - albeit significantly - muscle gains of +3.5 kg in older subjects on a high intensity resistance training regimen, it is highly questionable how capable the average "natural muscle builder" really is ... but let's not rant and rather take a look at what really works (for the elderly, at least).
So, the study at hand was actually not designed to elucidate the effects of testosterone on lean mass gains or fat loss, but rather to investigate testosterone's ability to augment or block the exercise-induced reductions in soluble CD36 a protein. CD36??? Well, I have to admit this is not exactly the best known inflammatory protein, but in view of the fact that it has been associated with the obesity induced increase in atherosclerosis risk (Handberg. 2006), it is an important one.
To quantify said effects, a group of Danish scientists measured the changes in soluble CD36 (sCD36) and body composition in response to a testosterone treatment (TT) and/or strength training (ST) in men with low-normal testosterone levels (Glintborg. 2015).
- the testosterone aka TT group in which the subjects were treated with 50–100 mg/day of testosterone from Testim per day (n= 20),
- the placebo aka PLA group in which the subjects were treated in which the subjects received an identically looking placebo supplement (n= 18),
- the strength training aka ST group in which the subjects followed a standardized progressive heavy strength training program (n= 16), and
- the combined groups with ST + TT or ST + PLA
|Figure 1: Changes in body composition (left) and bioavailable testosterone levels (right | Glintborg. 2015).|
And the effect was not just statistically, but also practically significant: Instead of the meager 0.6 kg without testosterone treatment, the subjects on T-gel gained a whopping 4.5 kg (that's +650%). That's truly impressive.
|Dose response relationship of muscle gain (in kg) per mg of testosterone enanthate from previous SV article; the white line indicates a dose that would probably have produce testosterone levels identical to baseline (calculated based on Bhasin. 2001 | learn more!)|
- Bhasin, Shalender, et al. "Testosterone dose-response relationships in healthy young men." American Journal of Physiology-Endocrinology And Metabolism 281.6 (2001): E1172-E1181.
- Febbraio, Maria, David P. Hajjar, and Roy L. Silverstein. "CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism." Journal of Clinical Investigation 108.6 (2001): 785.
- Glintborg, Dorte, et al. "Differential effects of strength training and testosterone treatment on soluble CD36 in aging men: Possible relation to changes in body composition." Scandinavian journal of clinical and laboratory investigation ahead-of-print (2015): 1-8.
- Haddad, Rudy M., et al. "Testosterone and cardiovascular risk in men: a systematic review and meta-analysis of randomized placebo-controlled trials." Mayo Clinic Proceedings. Vol. 82. No. 1. Elsevier, 2007.
- Handberg, Aase, et al. "Identification of the Oxidized Low-Density Lipoprotein Scavenger Receptor CD36 in Plasma A Novel Marker of Insulin Resistance." Circulation 114.11 (2006): 1169-1176.
- Kvorning, Thue, et al. "Mechanical Muscle Function and Lean Body Mass During Supervised Strength Training and Testosterone Therapy in Aging Men with Low‐Normal Testosterone Levels." Journal of the American Geriatrics Society 61.6 (2013): 957-962.
- Morgentaler, Abraham, et al. "Testosterone therapy and cardiovascular risk: advances and controversies." Mayo Clinic Proceedings. Vol. 90. No. 2. Elsevier, 2015.